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Title: Kinetics analysis of muscle arterial-venous O-2 difference profile during exercise
Authors: Barbosa, Priscila B. [UNIFESP]
Bravo, Daniela M. [UNIFESP]
Alberto Neder, J. [UNIFESP]
Ferreira, Leonardo F. [UNIFESP]
Univ Kentucky
Universidade Federal de São Paulo (UNIFESP)
Keywords: Oxygen pressure
Near-infrared spectroscopy
Oxygen delivery
Issue Date: 31-Aug-2010
Publisher: Elsevier B.V.
Citation: Respiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 173, n. 1, p. 51-57, 2010.
Abstract: Muscle vascular dysfunction: a hallmark of chronic diseases such as heart failure and diabetes, impairs the matching of blood flow (<(Q)over dot>(m)) to O-2 utilization (<(V)over dot>(O2m)) following exercise onset. One recently described consequence of this behavior is that arterial-venous O-2 difference [(a - v)(O2), the mirror image of muscle vascular oxygenation] transiently overshoots the subsequent steady-state and, in so doing, may provide important information regarding <(Q)over dot>(m) versus <(V)over dot>(O2m) dynamics. Using computer simulations, we tested the hypothesis that key parameters of the (a - v)(O2) overshoot - peak response, downward time constant (tau(D)), and total area - would relate quantitatively to <(Q)over dot>(m) kinetics. Our results demonstrated significant proportionality (all p < 0.01) between <(Q)over dot>(m) mean response time and peak (r(2) = 0.56), tau(D) (r(2) = 72) and total area (r(2) = 0.97) of (a - v)(O2) overshoot. These results suggest that analysis of (a - v)(O2) or its proxy, muscle vascular oxygenation [measured using near-infrared spectroscopy or phosphorescence quenching], provides valuable information regarding blood flow and vascular function particularly in reference to <(V)over dot>(O2m) kinetics. (C) 2010 Elsevier B.V. All rights reserved.
ISSN: 1569-9048
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