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Title: Controlled transscleral drug delivery formulations to the eye: establishing new concepts and paradigms in ocular anti-inflammatory therapeutics and antibacterial prophylaxis
Authors: Paganelli, Fernando [UNIFESP]
Cardillo, Jose A. [UNIFESP]
Dare, Alessandro R. J.
Melo, Luiz A. S. [UNIFESP]
Lucena, David R.
Silva, Arnobio A.
Oliveira, Anselmo G.
Pizzolitto, Antonio C.
Lavinsky, Daniel [UNIFESP]
Skaf, Mirian
Souza-Filho, Acacio A. [UNIFESP]
Hofling-Lima, Ana L. [UNIFESP]
Nguyen, Quan Dong
Kuppermann, Baruch D.
Herrero-Vanrell, Rocio
Belfort, Rubens [UNIFESP]
Brazilian Ocular Pharmacoloy & Pha
Hosp Olhos Araraquara
Universidade Federal de São Paulo (UNIFESP)
Univ Araraquara UNIARA
São Paulo State Univ UNESP
Johns Hopkins Univ
Univ Calif Irvine
Univ Complutense
Keywords: antibiotics
cataract surgery
eye drops
eye infections
intraocular penetration
ocular drug delivery
Issue Date: 1-Aug-2010
Publisher: Informa Healthcare
Citation: Expert Opinion On Drug Delivery. London: Informa Healthcare, v. 7, n. 8, p. 955-965, 2010.
Abstract: Importance of the field: the use of topical agents poses unique and challenging hurdles for drug delivery. Topical steroids effectively control ocular inflammation, but are associated with the well-recognized dilemma of patient compliance. Although administration of topical antimicrobials as prophylaxis is acceptable among ophthalmologists, this common practice has no sound evidence base Developing a new antimicrobial agent or delivery strategy with enhanced penetration by considering the anatomical and physiological constraints exerted by the barriers of the eye is not a commonly perceived strategy. Exploiting the permeability of the sclera, subconjunctival routes may offer a promising alternative for enhanced drug delivery and tissue targeting.Area covered in this review: Ocular drug delivery strategies were reviewed for ocular inflammation and infections clinically adopted for newer class of antimicrobials, which use a multipronged approach to limit risks of endophthalmitis.What the reader will gain: the analysis substantiates a new transscleral drug delivery therapeutic approach for cataract surgery.Take home message: A new anti-inflammatory and anti-infective paradigm that frees the patient from the nuisance of topical therapeutics is introduced, opening a large investigative avenue for future improved therapies.
ISSN: 1742-5247
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Appears in Collections:Artigo

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