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Title: Blockade of the Kinin B1 Receptor Ameloriates Glomerulonephritis
Authors: Klein, Julie
Gonzalez, Julien
Decramer, Stephane
Bandin, Flavio
Neau, Eric
Salant, David J.
Heeringa, Peter
Pesquero, Joao-Bosco [UNIFESP]
Schanstra, Joost-Peter
Bascands, Jean-Loup
Univ Toulouse 3
Hop Purpan
Boston Univ
Univ Groningen
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jul-2010
Publisher: Amer Soc Nephrology
Citation: Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 21, n. 7, p. 1157-1164, 2010.
Abstract: Severe inflammation characterizes rapidly progressive glomerulonephritides, and expression of the kinin B1 receptor (B1R) associates with inflammation. Delayed B1R blockade reduces renal inflammation in a model of unilateral ureteral obstruction, but whether B1R modulates the pathophysiology of glomerulonephritides is unknown. Here, we observed an association of B1R protein expression and inflammation, in both glomeruli and the renal interstitium, in biopsies of patients with glomerulonephritides, HenochSchonlein purpura nephropathy, and ANCA-associated vasculitis. in the nephrotoxic serum induced glomerulonephritis model, we observed upregulation of the B1R receptor; treatment with a B1R antagonist beginning 2 weeks after the onset of disease reduced both glomerular and tubular lesions and improved renal function. B1R blockade reduced renal chemokine expression and macrophage accumulation. Collectively, our data demonstrate that blockade of the kinin B1R has significant potential for the treatment of glomerulonephritis.
ISSN: 1046-6673
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