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Title: The Role of Host Factors and Bacterial Virulence Genes in the Development of Pyelonephritis Caused by Escherichia coli in Renal Transplant Recipients
Authors: Siliano, Priscila Reina [UNIFESP]
Rocha, Lillian Andrade [UNIFESP]
Pestana, Jose Osmar Medina [UNIFESP]
Heilberg, Ita Pfeferman [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jul-2010
Publisher: Amer Soc Nephrology
Citation: Clinical Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 5, n. 7, p. 1290-1297, 2010.
Abstract: Background and objectives: the aim of this study was to determine the role of host factors and bacterial virulence genes in the development of pyelonephritis caused by Escherichia coli in renal transplant (Tx) recipients.Design, setting, participants, & measurements: A total of 328 E. coli isolates from cases of cystitis (Cys; n = 239) or pyelonephritis (PN; n = 89), with 169 from renal Tx recipients, were subjected to molecular analyses to identify P-fimbria subunits (PapC, PapG II, and PapGIII), G- and M-fimbriae, and aerobactin. the presence of antibiotic resistance was also determined. Parameters such as gender, age, immunosuppression regimens, causes of ESRD, kidney donor, intraoperative anastomosis, use of double J stent, trimethoprim/sulfamethoxazole (TMP/SMZ) prophylaxis, and time after Tx were evaluated.Results: A multivariate analysis showed a significant association between PN and renal Tx. in renal Tx recipients, the risk of occurrence of PN was significantly higher among males and for those no longer receiving TMP/SMZ prophylaxis. E. coli strains isolated from PN presented a lower prevalence of papGIII and lower rates of resistance to pipemidic acid. Although papGII was more prevalent in PN than in Cys, it was not independently associated with PN.Conclusions: These findings suggested that renal Tx increases the risk for PN, and the male sex represented a host factor independently associated with risk, whereas the prophylaxis with TMP/SMZ was protective. the lack of papGIII and low resistance to first-generation quinolones were bacterial-independent risk factors for PN in Tx. Clin J Am Soc Nephrol 5: 1290-1297, 2010. doi: 10.2215/CJN.06740909
ISSN: 1555-9041
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