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https://repositorio.unifesp.br/handle/11600/32623
Title: | Synergistic effect of simvastatin and ezetimibe on lipid and pro-inflammatory profiles in pre-diabetic subjects |
Authors: | Kater, Ana-Lucia A. [UNIFESP] Batista, Marcelo C. [UNIFESP] Ferreira, Sandra R. G. Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
Issue Date: | 7-Jun-2010 |
Publisher: | Biomed Central Ltd |
Citation: | Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 2, 7 p., 2010. |
Abstract: | Background: Ezetimibe specifically blocks the absorption of dietary and biliary cholesterol and plant sterols. Synergism of ezetimibe-statin therapy on LDL-cholesterol has been demonstrated, but data concerning the pleiotropic effects of this combination are controversial.Objective: This open-label trial evaluated whether the combination of simvastatin and ezetimibe also results in a synergistic effect that reduces the pro-inflammatory status of pre-diabetic subjects.Methods: Fifty pre-diabetic subjects were randomly assigned to one of 2 groups, one receiving ezetimibe (10 mg/day), the other, simvastatin (20 mg/d) for 12 weeks, followed by an additional 12-week period of combined therapy. Blood samples were collected at baseline, 12 and 24 weeks. RESULTS: Total cholesterol, LDL-cholesterol and apolipoprotein B levels decreased in all the periods analyzed (p < 0.01), but triglycerides declined significantly only after combined therapy. Both drugs induced reductions in C-reactive protein, reaching statistical significance after combining ezetimibe with the simvastatin therapy (baseline 0.59 +/- 0.14, simvastatin monotherapy 0.48 +/- 0.12 mg/dL and 0.35 +/- 0.12 mg/dL, p < 0.023). Such a reduction was independent of LDL-cholesterol change. However, mean levels of TNF-alpha and interleukin-6 and leukocyte count did not vary during the whole study.Conclusion: Expected synergistic lowering effects of a simvastatin and ezetimibe combination on LDL-cholesterol, apolipoprotein B and triglycerides levels were confirmed in subjects with early disturbances of glucose metabolism. We suggest an additive effect of this combination also on inflammatory status based on the reduction of C-reactive protein. Attenuation of pro-inflammatory conditions may be relevant in reducing cardiometabolic risk. |
URI: | http://repositorio.unifesp.br/handle/11600/32623 |
ISSN: | 1758-5996 |
Other Identifiers: | http://dx.doi.org/10.1186/1758-5996-2-34 |
Appears in Collections: | Em verificação - Geral |
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WOS000290260300001.pdf | 672.43 kB | Adobe PDF | View/Open |
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