Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/32606
Title: The Ultrastructural Study of Tumorigenic Cells Using Nanobiomarkers
Authors: Pavon, Lorena Favaro
Marti, Luciana Cavalheiro
Sibov, Tatiana Tais
Malheiros, Suzana M. F. [UNIFESP]
Oliveira, Daniela Mara
Guilhen, Daiane Donna
Camargo-Mathias, Maria Izabel
Amaro Junior, Edson
Gamarra, Lionel Fernel
SBIBHAE
IIEPAE
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Sao Joao Del Rei
UNESP
Universidade de São Paulo (USP)
Keywords: cancer diagnosis
glioblastoma
immunolocalization
markers
nanoparticles
ultrastructural
Issue Date: 1-Jun-2010
Publisher: Mary Ann Liebert Inc
Citation: Cancer Biotherapy and Radiopharmaceuticals. New Rochelle: Mary Ann Liebert Inc, v. 25, n. 3, p. 289-298, 2010.
Abstract: Despite recent advances, patients with malignant brain tumors still have a poor prognosis. Glioblastoma (WHO grade 4 astrocytoma), the most malignant brain tumor, represents 50% of all astrocytomas, with a median survival rate of <1 year. It is, therefore, extremely important to search for new diagnostic and therapeutic approaches for patients with glioblastoma. This study describes the application of superparamagnetic nano-particles of iron oxide, as well as monoclonal antibodies, of immunophenotypic significance, conjoined to quantum dots for the ultrastructural assessment of glioblastoma cells. for this proposal, an immunophenotypic study by flow cytometry was carried out, followed by transmission electron microscopy analysis. the process of tumor cell labeling using nanoparticles can successfully contribute to the identification of tumorigenic cells and consequently for better understanding of glioblastoma genesis and recurrence. in addition, this method may help further studies in tumor imaging, diagnosis, and prognostic markers detection.
URI: http://repositorio.unifesp.br/handle/11600/32606
ISSN: 1084-9785
Other Identifiers: http://dx.doi.org/10.1089/cbr.2009.0697
Appears in Collections:Em verificação - Geral

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