Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/32593
Title: Mycobacterium chelonae valve endocarditis resulting from contaminated biological prostheses
Authors: Strabelli, T. M. V.
Siciliano, Rinaldo Focaccia
Castelli, Jussara Bianchi
Demarchi, L. M. M. F.
Leao, Sylvia Cardoso [UNIFESP]
Viana-Niero, Cristina [UNIFESP]
Miyashiro, Kozue
Sampaio, Roney Orismar
Grinberg, Max
Uip, David Everson
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Inst Fleury
Keywords: Endocarditis
Mycobacterium chelonae
Prostheses
Cardiac valve
Issue Date: 1-Jun-2010
Publisher: W B Saunders Co Ltd
Citation: Journal of Infection. London: W B Saunders Co Ltd, v. 60, n. 6, p. 467-473, 2010.
Abstract: Objectives: A rapid-growing mycobacteria biological prosthetic valve (BPV) endocarditis related to prosthetic manufacturing process is described in Brazil.Methods: From 1999 to 2008, thirty-nine patients underwent BPV replacement due to culture-negative suspected endocarditis. All these cases had histological sections stained by Ziehl-Neelsen method. Clinical and microbiological data were reviewed in all acid-fast bacilli (AFB) positive cases. the 16S-23S internal transcribed sequence (ITS) was amplified using DNA extracted from paraffin-embedded samples, digested with restrictions enzymes and/or sequenced.Results: Eighteen AFB positive BPV (18/39)(46%) were implanted in 13 patients and were from the same manufacturer. Four of them were implanted in other hospitals. Thirteen BPV were histologically proven endocarditis and five showed a colonization pattern. the examination of six non-implanted sterile BPV from this manufacturer resulted in 5 AFB positive. Mycobacterium chelonae was the AFB identified by ITS restriction analysis and sequencing.Conclusions: Rapid-growing mycobacteria infections must be suspected and Ziehl-Neelsen stain always performed on histology of either early or late BPV endocarditis, particularly when blood cultures are negative. (C) 2010 the British Infection Society. Published by Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/32593
ISSN: 0163-4453
Other Identifiers: http://dx.doi.org/10.1016/j.jinf.2010.03.008
Appears in Collections:Em verificação - Geral

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