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Title: Exercise prevents the effects of experimental arthritis on the metabolism and function of immune cells
Authors: Navarro, Francisco
Bacurau, Alinc V. N.
Almejda, Sandro S. [UNIFESP]
Barros, Carlos C. [UNIFESP]
Moraes, Milton R. [UNIFESP]
Pesquero, Jorge L.
Ribeiro, Sandra M. L.
Araujo, Ronaldo C. [UNIFESP]
Costa Rosa, Luis F. B. P.
Bacurau, Reury Frank Pereira
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: lymphocytes
rheumatoid arthritis
Issue Date: 1-Jun-2010
Publisher: Wiley-Blackwell
Citation: Cell Biochemistry and Function. Chichester: John Wiley & Sons Ltd, v. 28, n. 4, p. 266-273, 2010.
Abstract: Active lymphocytes (LY) and macrophages (M Phi) are involved in the pathophysiology of rheumatoid arthritis (RA) Due to its anti-inflammatory effect. physical exercise may be beneficial in RA by acting on the immune system (IS) Thus, female Wistar rats with type II collagen-induced arthritis (CIA) were submitted to swimming training (6 weeks. 5 days/week. 60 min/day) and some biochemical and immune parameters, such as the metabolism of glucose and glutamine and function of LY and M. were evaluated in addition, plasma levels of some hormones and of interleukin-2 (IL-2) were also determined Results demonstrate that CIA increased lymphocyte proliferation (1.9- and 1 7-fold, respectively, in response to concanavalin A (ConA) and lipopolysaccharide (LPS)), as well as macrophage H(2)O(2) production (1 6-fold), in comparison to control Exercise training prevented the activation of immune cells, induced by CIA. and established a pattern of substrate utilization similar to that described as normal for these cells. Exercise also promoted an elevation of plasma levels of corticosterone (22 2%), progesterone (1 7-fold) and IL-2 (2 6-fold) Our data suggest that chronic exercise is able to counterbalance the effects of CIA on cells of the IS. reinforcing the proposal that the benefits of exercise may not be restricted to aerobic capacity and/or strength improvement Copyright (C) 2010 John Wiley & Sons, Ltd
ISSN: 0263-6484
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