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Title: Degenerative parkinsonism in patients with psychogenic parkinsonism: A dopamine transporter imaging study
Authors: Felicio, Andre C. [UNIFESP]
Godeiro-Junior, Clecio [UNIFESP]
Moriyama, Tais S. [UNIFESP]
Shih, Ming C. [UNIFESP]
Hoexter, Marcelo Q. [UNIFESP]
Borges, Vanderci [UNIFESP]
Silva, Sonia M. A. [UNIFESP]
Aguiar, Patricia de Carvalho [UNIFESP]
Andrade, Luiz A. F.
Bressan, Rodrigo A. [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
H Israelita Albert Einstein
Keywords: Psychogenic parkinsonism
Parkinson's Disease
Dopamine transporter
Issue Date: 1-May-2010
Publisher: Elsevier B.V.
Citation: Clinical Neurology and Neurosurgery. Amsterdam: Elsevier B.V., v. 112, n. 4, p. 282-285, 2010.
Abstract: Objectives: To evaluate patients with clinically established psychogenic parkinsonism (PsyP) using single-photon emission computer tomography (SPECT)with the technetium-99m labeled tracer TRODAT-1, a dopamine transporter (DAT) ligand, and investigate whether these patients have an underlying degenerative parkinsonism.Patients and methods: Five patients with PsyP were assessed using demographic data, standard clinical scales for Parkinson's Disease (PD), and a neuropsychiatric interview. DAT imaging using SPECT with TRODAT-1 was performed, and values for caudate/putamen DAT binding potentials (BP) registered. Patients with PsyP were matched with PD (n = 5) and healthy control subjects (n = 5).Results: the mean age (years-old) at first evaluation in the PsyP group was 37.4 +/- 3.7, and the mean disease duration (years) was 3.9 +/- 1.2. DAT BPs (means +/- standard deviations) on right/left caudate were, respectively, 0.69 +/- 0.18 and 0.70 +/- 0.18 in the PD group versus 1.17 +/- 0.06 and 1.12 +/- 0.10 in the control group. DAT BPs on right/left putamen were, respectively, 0.48 +/- 0.10 and 0.45 +/- 0.06 in the PD group versus 1.10 +/- 0.10 and 1.21 +/- 0.43 in the control group. Two out of five patients from the PsyP group had values for DAT BP in the putamen under the cut-off (<= 0.70) for controls, implying pre-synaptic dopaminergic deficit.Conclusions: Our data in this small group of patients suggest that DAT imaging is a tool that may help in the identification of underlying degenerative parkinsonism in PsyP. (C) 2009 Elsevier B.V. All lights reserved.
ISSN: 0303-8467
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