Please use this identifier to cite or link to this item:
Title: VEGF Promotes Malaria-Associated Acute Lung Injury in Mice
Authors: Epiphanio, Sabrina [UNIFESP]
Campos, Marta G.
Pamplona, Ana
Carapau, Daniel
Pena, Ana C.
Ataide, Ricardo
Monteiro, Carla A. A.
Felix, Nuno
Costa-Silva, Artur
Marinho, Claudio R. F.
Dias, Sergio
Mota, Maria M.
Univ Lisbon
Univ Tecn Lisboa
Inst Gulbenkian Ciencias
Fac Med Lisbon
Universidade de São Paulo (USP)
Ctr Reg Oncol Lisboa
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-May-2010
Publisher: Public Library Science
Citation: Plos Pathogens. San Francisco: Public Library Science, v. 6, n. 5, 10 p., 2010.
Abstract: The spectrum of the clinical presentation and severity of malaria infections is broad, ranging from uncomplicated febrile illness to severe forms of disease such as cerebral malaria (CM), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), pregnancy-associated malaria (PAM) or severe anemia (SA). Rodent models that mimic human CM, PAM and SA syndromes have been established. Here, we show that DBA/2 mice infected with P. berghei ANKA constitute a new model for malaria-associated ALI. Up to 60% of the mice showed dyspnea, airway obstruction and hypoxemia and died between days 7 and 12 post-infection. the most common pathological findings were pleural effusion, pulmonary hemorrhage and edema, consistent with increased lung vessel permeability, while the blood-brain barrier was intact. Malaria-associated ALI correlated with high levels of circulating VEGF, produced de novo in the spleen, and its blockage led to protection of mice from this syndrome. in addition, either splenectomization or administration of the anti-inflammatory molecule carbon monoxide led to a significant reduction in the levels of sera VEGF and to protection from ALI. the similarities between the physiopathological lesions described here and the ones occurring in humans, as well as the demonstration that VEGF is a critical host factor in the onset of malaria-associated ALI in mice, not only offers important mechanistic insights into the processes underlying the pathology related with malaria but may also pave the way for interventional studies.
ISSN: 1553-7366
Other Identifiers:
Appears in Collections:Em verificação - Geral

Files in This Item:
File Description SizeFormat 
WOS000278759900035.pdf2.81 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.