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dc.contributor.authorSong Watanabe, Sung Eun [UNIFESP]
dc.contributor.authorBerezovsky, Adriana [UNIFESP]
dc.contributor.authorMotono, Marcia [UNIFESP]
dc.contributor.authorSacai, Paula Yuri [UNIFESP]
dc.contributor.authorPereira, Josenilson Martins [UNIFESP]
dc.contributor.authorSallum, Juliana Maria Ferraz [UNIFESP]
dc.contributor.authorGebrim, Luiz Henrique [UNIFESP]
dc.contributor.authorSalomão, Solange Rios [UNIFESP]
dc.identifier.citationDocumenta Ophthalmologica. Dordrecht: Springer, v. 120, n. 2, p. 137-143, 2010.
dc.description.abstractTamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. the purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 +/- A 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 +/- A 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 +/- A 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.relation.ispartofDocumenta Ophthalmologica
dc.rightsAcesso restrito
dc.subjectRetinal toxicityen
dc.subjectBreast canceren
dc.titleRetinal function in patients treated with tamoxifenen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Discipline Mastol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Discipline Mastol, São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 01/03364-6
dc.description.sourceWeb of Science
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