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Title: Retinal function in patients treated with tamoxifen
Authors: Song Watanabe, Sung Eun [UNIFESP]
Berezovsky, Adriana [UNIFESP]
Motono, Marcia [UNIFESP]
Sacai, Paula Yuri [UNIFESP]
Pereira, Josenilson Martins [UNIFESP]
Sallum, Juliana Maria Ferraz [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
Salomão, Solange Rios [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Tamoxifen
Retinal toxicity
Breast cancer
Issue Date: 1-Apr-2010
Publisher: Springer
Citation: Documenta Ophthalmologica. Dordrecht: Springer, v. 120, n. 2, p. 137-143, 2010.
Abstract: Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. the purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 +/- A 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 +/- A 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 +/- A 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer.
ISSN: 0012-4486
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