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Title: Changes in the Production of IL-10 and TNF-alpha in Skeletal Muscle of Rats with Heart Failure Secondary to Acute Myocardial Infarction
Authors: Lopes, Renato Delacio [UNIFESP]
Batista Junior, Miguel Luiz
Rosa, Jose Cesar
Lira, Fabio Santos de [UNIFESP]
Martins, Eivor
Shimura, Alex Yamashita
Brum, Patricia Chakur
Lancha, Antonio Herbert
Seelaender, Martha C. L.
Lopes, Antonio Carlos [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Mogi das Cruzes
Duke Clin Res Inst
Keywords: Ventricular dysfunction, left
muscle, skeletal
Issue Date: 1-Mar-2010
Publisher: Arquivos Brasileiros Cardiologia
Citation: Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 94, n. 3, p. 313-320, 2010.
Abstract: Background: Recent studies show that the expression of inflammatory mediators, such as cytokines, is an important factor for the development and progression of heart failure (HF), especially in the presence of left ventricular dysfunction. These changes have been demonstrated both in the plasma and heart muscle and, more recently, in skeletal muscle of rats and in patients with HF.Objective: To investigate the production and expression of tumor necrosis factor-alpha (TNF) and interleukin-10 (IL-10) in the soleus and the extensor digitorum longus (EDL) muscles of animals with left ventricular dysfunction after myocardial infarction (MI).Methods: We used male Wistar rats that underwent ligation of the left coronary artery without reperfusion. Four weeks after this procedure, the animals underwent echocardiography and were divided into the following experimental groups: sham operated (sham) and IM. They remained under observation for a further period of 8 weeks.Results: the level of the cytokine TNF-alpha increased by 26.5% (p <0.05), and its gene expression increased 3 times (p <0.07). the level of IL-70 decreased by 38.2% (p <0.05). Both changes occurred only in the soleus muscle, with no change in the EDL. the decrease (36.5%, p <0.05) in the IL-10/TNF-alpha ratio was due to both increased tissue levels of TNF-alpha and decreased tissue levels of IL-10.Conclusion: Our results showed significant changes in the IL-10/TNF-alpha ratio, which may have an additive role in the assessment of deterioration and progression of left ventricular dysfunction post-MI. Furthermore, our study suggests that these changes seem to be related to the muscle fiber type. (Arq Bras Cardiol 2010; 94(3):293-300)
ISSN: 0066-782X
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