Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/32153
Title: Intima-Media Thickness Is Associated with Inflammation and Traditional Cardiovascular Risk Factors in Non-Dialysis-Dependent Patients with Chronic Kidney Disease
Authors: Lemos, Marcelo M. [UNIFESP]
Jancikic, Alessandra D. B. [UNIFESP]
Sanches, Fabiana M. R. [UNIFESP]
Christofalo, Dejaldo M. [UNIFESP]
Ajzen, Sergio A. [UNIFESP]
Carvalho, Aluizio B. [UNIFESP]
Draibe, Sergio A. [UNIFESP]
Canziani, Maria Eugenia F. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Intima-media thickness
Inflammation
Cardiovascular disease
Chronic kidney disease
Issue Date: 1-Jan-2010
Publisher: Karger
Citation: Nephron Clinical Practice. Basel: Karger, v. 115, n. 3, p. C189-C194, 2010.
Abstract: Background: Mortality due to cardiovascular causes is high in chronic kidney disease (CKD). Intima-media thickness (IMT) and inflammation are early atherosclerosis markers, although data are lacking about their association in the CKD non-dialysis-dependent (CKD-NDD) population. the aim of the present study was to evaluate the association between IMT, inflammation and other cardiovascular risk factors in such patients. Methods: CKD-NDD patients (n = 122) were subjected to measurements of carotid IMT and inflammatory marker levels in a cross-sectional study. Results: Mean patient age was 55.2 +/- 11.3 years (61.5% males). Median C-reactive protein (CRP) was 0.28 mg/dl (0.03-14.2). the median interleukin (IL)-6 count was 4.75 pg/ml (0.7-243), the mean adiponectin was 27.8 +/- 7.3 ng/ml and the mean IMT was 0.61 +/- 0.19 mm. Four (3.3%) patients had IMT above the normal range. IMT was higher in males (p < 0.001), patients with estimated glomerular filtration rate < 60 ml/min (p = 0.030), inflammation (p = 0.005) and higher IL-6 levels (p = 0.023). IMT was correlated with age (R = 0.538; p < 0.001), waist circumference (R = 0.235; p = 0.016), CRP (R = 0.191; p = 0.035) and systolic blood pressure (R = 0.181; p = 0.048). in a multiple regression analysis, the independent determinants of IMT were age (beta = 0.512; p < 0.001) and CRP levels (beta = 0.159; p = 0.041). Conclusion: the present study demonstrated that although the IMT values were within the normal range, there was a clear association of IMT with age, as well as with inflammation in an asymptomatic CKD-NDD population. Copyright (C) 2010 S. Karger AG, Basel
URI: http://repositorio.unifesp.br/handle/11600/32153
ISSN: 1660-2110
Other Identifiers: http://dx.doi.org/10.1159/000313033
Appears in Collections:Em verificação - Geral

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