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dc.contributor.authorCysneiros, Roberta M.
dc.contributor.authorFerrari, Danuza [UNIFESP]
dc.contributor.authorArida, Ricardo M. [UNIFESP]
dc.contributor.authorTerra, Vera C.
dc.contributor.authorAlmeida, Antonio-Carlos G. de
dc.contributor.authorCavalheiro, Esper A. [UNIFESP]
dc.contributor.authorScorza, Fulvio A. [UNIFESP]
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 17, n. 1, p. 33-38, 2010.
dc.description.abstractStudies have provided evidence of the important effects of omega-3 fatty acid on the brain in neurological conditions, including epilepsy. Previous data have indicated that omega-3 fatty acids lead to prevention of status epilepticus-associated neuropathological changes in the hippocampal formation of rats with epilepsy. Omega-3 fatty acid supplementation has resulted in extensive preservation of GABAergic cells in animals with epilepsy. This study investigated the interplay of these effects with neurogenesis and brain-derived neurotrophic factor (BDNF). the results clearly showed a positive effect of long-term omega-3 fatty acid supplementation on brain plasticity in animals with epilepsy. Enhanced hippocampal neurogenesis and BDNF levels and preservation of interneurons expressing parvalbumin were observed. Parvalbumin-positive cells were identified as surviving instead of newly formed cells. Additional investigations are needed to determine the electrophysiological properties of the newly formed cells and to clarify whether the effects of omega-3 fatty acids on brain plasticity are accompanied by functional gain in animals with epilepsy. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCinAPCe (Brazil)
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsAcesso restrito
dc.subjectOmega-3 fatty acidsen
dc.subjectBrain-derived neurotrophic factoren
dc.subjectOral supplementationen
dc.titleQualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acidsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Fed Sao Joao Del Rei
dc.description.affiliationUNIFESP EPM, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Ctr Cirurgia Epilepsia CIREP, Dept Neurociencias & Ciencias Comportamento, São Paulo, Brazil
dc.description.affiliationUniv Fed Sao Joao Del Rei, Dept Biomed Engn, Sao Joao Del Rei, MG, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
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