Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/32108
Title: mRNA expression of matrix metalloproteinases (MMPs) 2 and 9 and tissue inhibitor of matrix metalloproteinases (TIMPs) 1 and 2 in childhood acute lymphoblastic leukemia: Potential role of TIMP1 as an adverse prognostic factor
Authors: Scrideli, Carlos Alberto
Abdala Cortez, Maria Angelica
Yunes, Jose Andres
Paula Queiroz, Rosane Gomes de
Valera, Elvis Terci
Mata, Juliana Franca da
Toledo, Silvia Regina Caminada de [UNIFESP]
Pavoni-Ferreira, Priscila [UNIFESP]
Martino Lee, Maria Lucia de [UNIFESP]
Petrilli, Antonio Sergio [UNIFESP]
Brandalise, Silvia Regina
Tone, Luiz Gonzaga
Universidade de São Paulo (USP)
Ctr Infantil Boldrini
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Keywords: Childhood ALL
MMP
TIMP
Prognostic factor
Issue Date: 1-Jan-2010
Publisher: Elsevier B.V.
Citation: Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 34, n. 1, p. 32-37, 2010.
Abstract: This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P = 0.04) and multivariable analysis (P = 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL. (c) 2009 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/32108
ISSN: 0145-2126
Other Identifiers: http://dx.doi.org/10.1016/j.leukres.2009.10.007
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