Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/32057
Title: Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglycerides in elderly men
Authors: Araujo, Lara Miguel Quirino [UNIFESP]
Cendoroglo, Maysa Seabra [UNIFESP]
Gigek, Carolina Oliveira [UNIFESP]
Chen, Elizabeth Suchi [UNIFESP]
Smith, Maria de Arruda Cardoso [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Lipoprotein lipase
Polymorphism
Triglycerides
HDL cholesterol
Elderly
Issue Date: 1-Jan-2010
Publisher: Funpec-editora
Citation: Genetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 9, n. 1, p. 89-96, 2010.
Abstract: Lipoprotein lipase is essential for triglyceride hydrolysis. the polymorphisms S447X in exon 9 and HindIII in intron 8 have been associated with lower triglyceride levels and lower cardiovascular risk in adult men. We examined the association of these lipoprotein lipase polymorphisms with high-density lipoprotein (HDL) and triglyceride levels in elderly men. Blood samples were obtained from 87 elderly men, 48 of whom had cardiovascular disease and 39 (controls) had no history of cardiovascular events. the lipoprotein lipase polymorphisms were analyzed by PCR-RFLP. Allele frequencies were H- = 27.9% and X = 21.5%. There were no significant differences in allele frequencies or blood lipid levels between cardiovascular disease and control groups. However, the X allele was associated with a lower triglyceride/HDL ratio, 2.30 vs 3.02 for X allele absent (P = 0.03); the H-X haplotype was associated with lower triglyceride levels compared to the H+ S haplotype (1.22 vs 1.58 mM, respectively) and a lower triglyceride/HDL ratio (2.29 vs 3.26, respectively). the X allele and H-X haplotype were associated with lower triglyceride/HDL ratios in these elderly men, independent of the history of cardiovascular events.
URI: http://repositorio.unifesp.br/handle/11600/32057
ISSN: 1676-5680
Other Identifiers: http://dx.doi.org/10.4238/vol9-1gmr689
Appears in Collections:Em verificação - Geral

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