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Title: Ghrelin and GHRP-6-induced ACTH and cortisol release in thyrotoxicosis
Authors: Nascif, Sergio Oliva [UNIFESP]
Molica, Patricia [UNIFESP]
Correa-Silva, Silvia Regina [UNIFESP]
Silva, Marcos Roberto [UNIFESP]
Lengyel, Ana-Maria Judith [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Ghrelin
Issue Date: 1-Dec-2009
Publisher: Springer
Citation: Pituitary. New York: Springer, v. 12, n. 4, p. 315-321, 2009.
Abstract: Thyrotoxicosis might alter the hypothalamic-pituitary-adrenal (HPA) axis. We evaluated the effects of ghrelin and GHRP-6 on the HPA axis in 20 hyperthyroid patients and in 9 controls. Mean basal cortisol (mu g/dl) and ACTH (pg/ml) levels were higher in hyperthyroidism (cortisol: 10.7 +/- A 0.7; ACTH: 21.5 +/- A 2.9) compared to controls (cortisol: 8.1 +/- A 0.7; ACTH: 13.5 +/- A 1.8). in thyrotoxicosis a dagger AUC cortisol values (mu g/dl.90 min) after ghrelin (484 +/- A 80) and GHRP-6 (115 +/- A 63) were similar to controls (ghrelin: 524 +/- A 107; GHRP-6: 192 +/- A 73). A significant increase in a dagger AUC ACTH (pg/ml.90 min) after ghrelin was observed in thyrotoxicosis (4,189 +/- A 1,202) compared to controls (1,499 +/- A 338). a dagger AUC ACTH values after GHRP-6 were also higher, although not significantly (patients: 927 +/- A 330; controls: 539 +/- A 237). in summary, our results suggest that ghrelin-mediated pathways of ACTH release might be activated by thyroid hormone excess, but adrenocortical reserve is maintained.
ISSN: 1386-341X
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