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Title: GB virus type C infection modulates T-cell activation independently of HIV-1 viral load
Authors: Maidana-Giret, Maria Teresa [UNIFESP]
Silva, Tania M. [UNIFESP]
Sauer, Mariana M. [UNIFESP]
Tomiyama, Helena [UNIFESP]
Levi, Jose Eduardo
Bassichetto, Katia Cristina
Nishiya, Anna
Diaz, Ricardo S. [UNIFESP]
Sabino, Ester Cerdeira [UNIFESP]
Palacios, Ricardo [UNIFESP]
Kallas, Esper Georges [UNIFESP]
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Publ Hlth Dept São Paulo
Fundacao Prosangue
Keywords: activation
GB virus type C
T lymphocyte
Issue Date: 13-Nov-2009
Publisher: Lippincott Williams & Wilkins
Citation: Aids. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 17, p. 2277-2287, 2009.
Abstract: Background: Many clinical studies have suggested a beneficial effect of GB virus type C (GBV-C) on the course of HIV-1 infection, but the mechanisms involved in such amelioration are not clear. As recent evidence has implicated cellular activation in HIV-1 pathogenesis, we investigated the effect of GBV-C viremia on T-cell activation in early HIV-1 infection.Methods: Forty-eight recently infected HIV-1 patients (23 GBV-C viremic) were evaluated for T-cell counts, expanded immunophenotyping GBV-C RNA detection, and HIV-1 viral load. Nonparametric univariate and multivariate analyses were carried out to identify variables associated with cellular activation, including GBV-C status, HIV-1 viral load, T lymphocyte counts, and CD38 and chemokine (C-C motif) receptor 5 (CCR5) surface expression.Finding: We not only confirmed the positive correlation between HIV-1 viral load and the percentage of T cells positive for CD38(+)CD8(+) but also observed that GBV-C viremic patients had a lower percentage of T cells positive for CD38(+)CD4(+), CD38(+)CD8(+), CCR5(+)CD4(+), and CCR5(+)CD8(+) compared with HIV-1-infected patients who were not GBV-C viremic. in regression models, GBV-C RNA(+) status was associated with a reduction in the CD38 on CD4(+) or CD8(+) T cells and CCR5(+) on CD8(+) T cells, independent of the HIV-1 viral load or CD4(+) and CD8(+) T-cell counts. These results were also supported by the lower expression of CD69 and CD25 in GBV-C viremic patients.Interpretation: the association between GBV-C replication and lower T-cell activation may be a key mechanism involved in the protection conferred by this virus against HIV-1 disease progression to immunodeficiency in HIV-1-infected patients. (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN: 0269-9370
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