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|Title:||Case Report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors|
Manzano, Maria R.
Palacios, Ricardo [UNIFESP]
Velez, Juan Diego
Epstein, Judith E.
Reed, Zarifah Hussain
Ctr Int Vacunas
Univ Nacl Colombia
Universidade Federal de São Paulo (UNIFESP)
Fdn Clin Valle Lili
Family Hlth Int
Reg Emerging Dis Intervent REDI Ctr
|Publisher:||Amer Soc Trop Med & Hygiene|
|Citation:||American Journal of Tropical Medicine and Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 81, n. 5, p. 740-746, 2009.|
|Abstract:||Successful establishment of a Plasmodium vivax sporozoite challenge model in humans is described. Eighteen healthy adult, malaria-naive volunteers were randomly allocated to Groups A-C and exposed to 3 +/- 1, 6 +/- 1, and 9 +/- 1 bites of Anopheles albimanus mosquitoes infected with P vivax, respectively. Seventeen volunteers developed signs and symptoms consistent with malaria, and geometric mean prepatent periods of 11.1 days (9.3-11) for Group A; 10.8 days (9.8-11.9) for Group B; and 10.6 days (8.7-12.4) for Group C, with no statistically significant difference among groups (Kruskal-Wallis, P = 0.70). One volunteer exposed to eight mosquito bites did not develop a parasitemia. No differences in parasite density were observed and all individuals successfully recovered after anti-malarial treatment. None of the volunteers developed parasite relapses within an 18-month follow-up. in conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2-10 An. albimanus mosquitoes carrying P vivax. sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.|
|Appears in Collections:||Em verificação - Geral|
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