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Title: Case Report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors
Authors: Herrera, Socrates
Fernandez, Olga
Manzano, Maria R.
Murrain, Bermans
Vergara, Juana
Blanco, Pedro
Palacios, Ricardo [UNIFESP]
Velez, Juan Diego
Epstein, Judith E.
Chen-Mok, Mario
Reed, Zarifah Hussain
Arevalo-Herrera, Myriam
Ctr Int Vacunas
Univ Valle
Univ Nacl Colombia
Universidade Federal de São Paulo (UNIFESP)
Fdn Clin Valle Lili
Family Hlth Int
Reg Emerging Dis Intervent REDI Ctr
Issue Date: 1-Nov-2009
Publisher: Amer Soc Trop Med & Hygiene
Citation: American Journal of Tropical Medicine and Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 81, n. 5, p. 740-746, 2009.
Abstract: Successful establishment of a Plasmodium vivax sporozoite challenge model in humans is described. Eighteen healthy adult, malaria-naive volunteers were randomly allocated to Groups A-C and exposed to 3 +/- 1, 6 +/- 1, and 9 +/- 1 bites of Anopheles albimanus mosquitoes infected with P vivax, respectively. Seventeen volunteers developed signs and symptoms consistent with malaria, and geometric mean prepatent periods of 11.1 days (9.3-11) for Group A; 10.8 days (9.8-11.9) for Group B; and 10.6 days (8.7-12.4) for Group C, with no statistically significant difference among groups (Kruskal-Wallis, P = 0.70). One volunteer exposed to eight mosquito bites did not develop a parasitemia. No differences in parasite density were observed and all individuals successfully recovered after anti-malarial treatment. None of the volunteers developed parasite relapses within an 18-month follow-up. in conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2-10 An. albimanus mosquitoes carrying P vivax. sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.
ISSN: 0002-9637
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