Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/31909
Title: Case Report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors
Authors: Herrera, Socrates
Fernandez, Olga
Manzano, Maria R.
Murrain, Bermans
Vergara, Juana
Blanco, Pedro
Palacios, Ricardo [UNIFESP]
Velez, Juan Diego
Epstein, Judith E.
Chen-Mok, Mario
Reed, Zarifah Hussain
Arevalo-Herrera, Myriam
Ctr Int Vacunas
Univ Valle
Univ Nacl Colombia
Universidade Federal de São Paulo (UNIFESP)
Fdn Clin Valle Lili
USN
Family Hlth Int
Reg Emerging Dis Intervent REDI Ctr
WHO
Issue Date: 1-Nov-2009
Publisher: Amer Soc Trop Med & Hygiene
Citation: American Journal of Tropical Medicine and Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 81, n. 5, p. 740-746, 2009.
Abstract: Successful establishment of a Plasmodium vivax sporozoite challenge model in humans is described. Eighteen healthy adult, malaria-naive volunteers were randomly allocated to Groups A-C and exposed to 3 +/- 1, 6 +/- 1, and 9 +/- 1 bites of Anopheles albimanus mosquitoes infected with P vivax, respectively. Seventeen volunteers developed signs and symptoms consistent with malaria, and geometric mean prepatent periods of 11.1 days (9.3-11) for Group A; 10.8 days (9.8-11.9) for Group B; and 10.6 days (8.7-12.4) for Group C, with no statistically significant difference among groups (Kruskal-Wallis, P = 0.70). One volunteer exposed to eight mosquito bites did not develop a parasitemia. No differences in parasite density were observed and all individuals successfully recovered after anti-malarial treatment. None of the volunteers developed parasite relapses within an 18-month follow-up. in conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2-10 An. albimanus mosquitoes carrying P vivax. sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.
URI: http://repositorio.unifesp.br/handle/11600/31909
ISSN: 0002-9637
Other Identifiers: http://dx.doi.org/10.4269/ajtmh.2009.09-0194
Appears in Collections:Em verificação - Geral

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