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Title: Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents
Authors: Prado, Wagner Luiz do
Piano, Aline de [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Stella, Sergio Garcia
Tufik, Sergio [UNIFESP]
Oller do Nascimento, Claudia Maria [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Lofrano, Mara Cristina [UNIFESP]
Tock, Lian [UNIFESP]
Caranti, Danielle Arisa [UNIFESP]
Damaso, Ana Raimunda [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Univ Pernambuco
Univ Ribeirao Preto UNAERP
Keywords: Obesity
Bone mass
Body composition
Issue Date: 1-Sep-2009
Publisher: Springer
Citation: Journal of Bone and Mineral Metabolism. Tokyo: Springer Tokyo, v. 27, n. 5, p. 613-619, 2009.
Abstract: Despite the epidemic of adolescent obesity, the effect of obesity and hormones on bone mineral accrual during growth is poorly understood. Studies using dual-energy X-ray to examine the effect of obesity on bone mass in children and adolescents have yielded conflicting results. the aim of this study was to explore the combined and independent contributions of body mass index, body composition, leptin, insulin, glucose levels and Homeostasis Model Assessment Insulin Resistance (HOMA-IR) to bone mineral density (BMD) and bone mineral content in a group of Brazilian obese adolescents. This study included 109 post-pubescent obese adolescents. A whole-body dual-energy X-ray absorptiometry scan was performed,using a HOLOGIC QDR4200, to determine whole-body BMD and body composition. Blood samples were collected in the outpatient clinic after an overnight fast, and evaluated for fasting blood glucose and immunoreactive insulin. Leptin levels were assessed with a radioimmunoassay kit. Insulin resistance was assessed by HOMA-IR and the quantitative insulin sensitivity check index. Our results showed that insulin levels and HOMA-IR correlated negatively with BMD and a linear regression analysis showed that serum leptin is inversely associated to BMD adjusted for body mass. in conclusion, our data support the hypothesis that leptin, insulin and HOMA-IR are inversely associated with BMD and play a significant direct role in bone metabolism.
ISSN: 0914-8779
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