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Title: A Neuropsychological Study Comparing Patients Infected With HCV and HBV Without Psychiatric Comorbidities
Authors: Quarantini, Lucas C. [UNIFESP]
Miranda-Scippa, Angela
Batista-Neves, Susana
Powell, Vania B.
Abreu, Neander
Abreu, Katiusha C.
Moura, Ilka
Crane, Jacquelyn
Sampaio, Aline S.
Netto, Liana. R.
deOliveira, Irismar R.
Parana, Raymundo
Bressan, Rodrigo A. [UNIFESP]
Lacerda, Acioly L. T. . [UNIFESP]
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Harvard Univ
Universidade de São Paulo (USP)
Inst Sinapse Neurociencias Clin
Ctr Pesquisa & Ensaios Clin Sinapse Bairral
Keywords: hepatitis C virus
cognitive dysfunction
chronic liver disease
mental disorders
major depression
Issue Date: 1-Jul-2009
Publisher: Wiley-Blackwell
Citation: Journal of Medical Virology. Hoboken: Wiley-liss, v. 81, n. 7, p. 1184-1188, 2009.
Abstract: Hepatitis C is one of the most common chronic infectious diseases worldwide, with well-documented extra-hepatic manifestations, such as a broad number of cognitive deficits. These impairments may be explained by psychiatric comorbidities, which have not been investigated properly in the literature. in order to elucidate a specific hepatitis C virus (HCV) induced cognitive impairment not related to mental disorders, neuropsychological performance of patients infected with HCV was compared with that of patients infected with hepatitis B virus cognitive impairment, especially psychiatric comorbidities. A total of 33 patients infected with HCV and 22 patients infected with HBV were included in the study. There were no significant differences between the two groups with regard to age or years of education. the group of patients infected with HCV performed significantly worse on visuo-spatial memory tasks after adjusting for years of education and age. There were no significant differences between patients infected with HCV and patients infected with HBV with regards to other neuropsychological functions. the data indicate that patients infected with HCV patients have poorer visuo-spacial memory performance than patients infected with HBV, suggesting that the cognitive deficit may be specific to HCV infection and not to secondary comorbid psychiatric disorders. J. Med. Virol. 81: 1184-1188, 2009. (C) 2009 Wiley-Liss, Inc.
ISSN: 0146-6615
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