Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/31621
Title: A Single Intraoperative Sub-Tenon's Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery
Authors: Paganelli, Fernando [UNIFESP]
Cardillo, Jose A. [UNIFESP]
Melo Jr., Luiz Alberto Soares [UNIFESP]
Lucena, David R.
Silva, Arnobio A.
Oliveira, Anselmo G.
Hofling-Lima, Ana Luisa [UNIFESP]
Nguyen, Quan Dong
Kuppermann, Baruch D.
Belfort, Rubens Junior [UNIFESP]
Brazilian Ocular Pharmacology and Pharmaceutical Technology Research Group (BOPP)
Hosp Olhos Araraquara
Universidade Federal de São Paulo (UNIFESP)
Univ Araraquara
São Paulo State Univ
Johns Hopkins Univ
Univ Calif Irvine
Issue Date: 1-Jul-2009
Publisher: Assoc Research Vision Ophthalmology Inc
Citation: Investigative Ophthalmology & Visual Science. Rockville: Assoc Research Vision Ophthalmology Inc, v. 50, n. 7, p. 3041-3047, 2009.
Abstract: PURPOSE. To compare intraoperative injection of triamcinolone and ciprofloxacin in a controlled-release system (DuoCat) with prednisolone and ciprofloxacin eye drops after cataract surgery.METHODS. in this randomized, double-masked, controlled trial, a total of 135 patients undergoing cataract surgery were randomly allocated to two groups: 67 patients treated after surgery with prednisolone 1% and ciprofloxacin 3% eye drops four times daily (week 1), three times daily (week 2), twice daily (week 3), and once daily (week 4) and 0.3% ciprofloxacin drops four times daily (weeks 1 and 2), and 68 patients treated at the end of surgery with a sub-Tenon's injection of 25 mg triamcinolone and 2 mg ciprofloxacin in biodegradable microspheres. the patients were examined on postoperative days 1, 3, 7, 14, and 28. the main outcome measures were postoperative anterior chamber cell and flare, intraocular pressure (IOP), lack of anti-inflammatory response, and presence of infection.RESULTS. No significant differences were observed between the groups in anterior chamber cell (P > 0.14) and flare (P > 0.02) at any postoperative visits. the mean (99% confidence interval) differences in IOP between the prednisolone and triamcinolone groups on days 1, 3, 7, 14, and 28 were -0.4 mm Hg (-2.1 to 1.3), 0.0 mm Hg (-1.4 to 1.3), 0.0 mm Hg (-1.1 to 1.1), -0.2 mm Hg (-1.1 to 0.8), and -0.1 mm Hg (-1.1 to 0.9), respectively. No patient had a postoperative infection.CONCLUSIONS. One injection of DuoCat had a therapeutic response and ocular tolerance that were equivalent to conventional eye drops in controlling inflammation after cataract surgery. (Clinical-Trials. gov number, NCT00431028.) (Invest Ophthalmol Vis Sci. 2009; 50: 3041-3047) DOI: 10.1167/iovs.08-2920
URI: http://repositorio.unifesp.br/handle/11600/31621
ISSN: 0146-0404
Other Identifiers: http://dx.doi.org/10.1167/iovs.08-2920
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.