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Title: Plasma levels of FL and SDF-1 and expression of FLT-3 and CXCR4 on CD34+cells assessed pre and post hematopoietic stem cell mobilization in patients with hematologic malignancies and in healthy donors
Authors: Cecyn, Karin Zattar [UNIFESP]
Schimieguel, Dulce Marta [UNIFESP]
Sugano Kimura, Eliza Yuriko [UNIFESP]
Yamamoto, Mihoko [UNIFESP]
Rodrigues de Oliveira, Jose Salvador [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: PBSC
Adhesion molecules
Issue Date: 1-Jun-2009
Publisher: Elsevier B.V.
Citation: Transfusion and Apheresis Science. Oxford: Pergamon-Elsevier B.V., v. 40, n. 3, p. 159-167, 2009.
Abstract: Peripheral blood stem cells (PBSC) became the main source of cells for autologous transplantation. Alterations in the expression of adhesion molecules are essential in the CD34+ cells mobilization process. These molecules are involved in the interaction between hematopoietic and stromal cells and they have been disclosed as a considerable factor to the trafficking and homing of the CD34+ progenitor cells.This is a non-randomized PBSC mobilization study designed to evaluate the influence and behavior of FL and SDF-1 and their receptors in two different moments, prior and after HPCs mobilization, with the yield of CD34+ cells collected by apheresis.There was higher concentration of FL and lower of SDF-1 plasma level at post than pre PBSC mobilization (p = 0.001 and p m 0.012, respectively) regarding all individuals searched, but without any correlation with a good yield of CD34+ cells. However, CXCR4 expressions on the CD34+ cells from bone marrow aspirates (BMA), at pre and post mobilization showed a difference statistical significant for those individuals with good yield of CD34+ cells (p = 0,036), but not achieved for poor yield (p = 0,156). There was a higher expression of CXCR4 in steady-state for the Successfully individuals than for those unsuccessfully (529.84 +/- 54.68 and 496.31 +/- 97.51, respectively). in conclusion, we confirmed the important role of CXCR4/SDF-1 axis in the process of PBSC mobilization. (C) 2009 Elsevier B.V. All rights reserved.
ISSN: 1473-0502
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