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Title: Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training
Authors: Bacurau, Aline V. N.
Jardim, Maira A.
Ferreira, Julio C. B.
Bechara, Luiz R. G.
Bueno, Carlos R.
Alba-Loureiro, Tatiana C.
Negrao, Carlos E.
Casarini, Dulce E. [UNIFESP]
Curi, Rui
Ramires, Paulo R.
Moriscot, Anselmo S.
Brum, Patricia C.
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: oxidative stress
alpha(2A)/alpha(2C)-adrenergic receptor knockout mice
cardiac cachexia
Issue Date: 1-May-2009
Publisher: Amer Physiological Soc
Citation: Journal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 106, n. 5, p. 1631-1640, 2009.
Abstract: Bacurau AV, Jardim MA, Ferreira JC, Bechara LR, Bueno CR Jr, Alba-Loureiro TC, Negrao CE, Casarini DE, Curi R, Ramires PR, Moriscot AS, Brum PC. Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training. J Appl Physiol 106: 1631-1640, 2009. First published January 29, 2009; doi:10.1152/japplphysiol.91067.2008.-Sympathetic hyperactivity (SH) is a hallmark of heart failure (HF), and several lines of evidence suggest that SH contributes to HF-induced skeletal myopathy. However, little is known about the influence of SH on skeletal muscle morphology and metabolism in a setting of developing HF, taking into consideration muscles with different fiber compositions. the contribution of SH on exercise tolerance and skeletal muscle morphology and biochemistry was investigated in 3- and 7-mo-old mice lacking both alpha(2A)- and alpha(2C)-adrenergic receptor subtypes (alpha(2A)/alpha(2C)ARKO mice) that present SH with evidence of HF by 7 mo. To verify whether exercise training (ET) would prevent skeletal muscle myopathy in advanced-stage HF, alpha(2A)/alpha(2C)ARKO mice were exercised from 5 to 7 mo of age. At 3 mo, alpha(2A)/alpha(2C)ARKO mice showed no signs of HF and preserved exercise tolerance and muscular norepinephrine with no changes in soleus morphology. in contrast, plantaris muscle of alpha(2A)/alpha(2C)ARKO mice displayed hypertrophy and fiber type shift (IIA -> IIX) paralleled by capillary rarefaction, increased hexokinase activity, and oxidative stress. At 7 mo, alpha(2A)/alpha(2C)ARKO mice displayed exercise intolerance and increased muscular norepinephrine, muscular atrophy, capillary rarefaction, and increased oxidative stress. ET reestablished alpha(2A)/alpha(2C)ARKO mouse exercise tolerance to 7-mo-old wild-type levels and prevented muscular atrophy and capillary rarefaction associated with reduced oxidative stress. Collectively, these data provide direct evidence that SH is a major factor contributing to skeletal muscle morphological changes in a setting of developing HF. ET prevented skeletal muscle myopathy in alpha(2A)/alpha(2C)ARKO mice, which highlights its importance as a therapeutic tool for HF.
ISSN: 8750-7587
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