Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/31477
Title: Uric Acid as a Marker for Renal Dysfunction in Hypertensive Women on Diuretic and Nondiuretic Therapy
Authors: Borges, Rodolfo. L. [UNIFESP]
Hirota, Andrea H. [UNIFESP]
Quinto, Beata M. [UNIFESP]
Ribeiro, Artur B. [UNIFESP]
Zanella, Maria T. [UNIFESP]
Batista, Marcelo C. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-May-2009
Publisher: Wiley-Blackwell
Citation: Journal of Clinical Hypertension. Malden: Wiley-Blackwell Publishing, Inc, v. 11, n. 5, p. 253-259, 2009.
Abstract: Hyperuricemia is a common finding in hypertensive patients, especially among those who are on diuretic therapy. However, its clinical relevance regarding cardiovascular and chronic kidney disease (CKD) has not clearly been established. the authors assessed whether, in a population of 385 hypertensive women categorized according to diuretic therapy, the stratification in quartiles by uric acid levels would identify a gradient of changes in renal function and in risk factors for cardiovascular disease. the following were evaluated: serum uric acid, glycemia, total and fractional cholesterol, triglycerides, apolipoprotein (Apo) B, Apo A-I, and C-reactive protein. Renal function was assessed by serum creatinine, albuminuria, and estimated glomerular filtration rate (eGFR) by the Modification of Diet in Renal Disease equation, whereas cardiovascular risk was estimated through the Framingham score. A total of 246 women were on diuretic therapy; 139 were taking other antihypertensive medications. There was a reduction in eGFR parallel to the increase in uric acid levels, regardless of diuretic use and without a concomitant increase in albuminuria. in both groups, higher uric acid levels translated into an increase in metabolic syndrome components, in markers of insulin resistance, triglyceride/high-density lipoprotein levels, and Apo B/Apo A-I ratios, as well as in Framingham scores. Hyperuricemia was associated with an increase in inflammatory markers only in patients on diuretic therapy. in a binary logistic regression, hyperuricemia (uric acid > 6.0 mg/dL) was independently associated with CKD (eGFR < 60 mL/min/1.73 m(2)) (odds ratio, 2.63; 95% confidence interval, 1.61-4.3; P <.001). in hypertensive women, the presence of hyperuricemia indicated a substantial degree of kidney dysfunction as well as a greater cardiovascular risk profile.
URI: http://repositorio.unifesp.br/handle/11600/31477
ISSN: 1524-6175
Other Identifiers: http://dx.doi.org/10.1111/j.1751-7176.2009.00101.x
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.