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Title: Does mobilization for autologous stem cell transplantation damage stromal layer formation?
Authors: Schimieguel, Dulce Marta [UNIFESP]
Dominato, Juliana Augusta Albieri [UNIFESP]
Zattar, Karin Cecyn [UNIFESP]
Regis Silva, Maria Regina [UNIFESP]
Souza, Marlon Knabben de [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Borelli, Primavera
Rodrigues de Oliveira, Jose Salvador [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Autologous stem cell transplantation
long-term bone marrow culture
Issue Date: 1-Apr-2009
Publisher: Maney Publishing
Citation: Hematology. Leeds: Maney Publishing, v. 14, n. 2, p. 76-83, 2009.
Abstract: Autologous hematopoietic stem cell transplantation (HSCT) has proved efficient to treat hematological malignancies. However, some patients fail to mobilize HSCs. It is known that the microenvironment may undergo damage after allogeneic HSCT. However little is known about how chemotherapy and growth factors contribute to this damage. We studied the stromal layer formation(SLF) and velocity before and after HSC mobilization, through long-term bone marrow culture from 22 patients and 10 healthy donors. Patients' SLF was similar at pre- (12/22)and post-mobilization (9/20), however for controls this occurred more at pre- mobilization (9/10; p=0.03). SLF velocity was higher at pre than post-mobilization in both groups. Leukemias and multiple myeloma showed faster growth of SLF than lymphomas at post-mobilization, the latter being similar to controls. These findings could be explained by less uncommitted HSC in controls than patients at post-mobilization. Control HSCs may migrate more in response to mobilization, resulting in a reduced population by those cells.
ISSN: 1024-5332
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