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Title: Electrophysiological Effects of Late Percutaneous Coronary Intervention for Infarct-Related Coronary Artery Occlusion the Occluded Artery Trial-Electrophysiological Mechanisms (OAT-EP)
Authors: Rashba, Eric J.
Lamas, Gervasio A.
Couderc, Jean-Philippe
Hollist, Sharri M.
Dzavik, Vladimir
Ruzyllo, Witold
Fridrich, Viliam
Buller, Christopher E.
Forman, Sandra A.
Kufera, Joseph A.
Carvalho, Antonio Carlos [UNIFESP]
Hochman, Judith S.
OAT-EP Investigators
SUNY Stony Brook
Mt Sinai Med Ctr
Univ Rochester
Univ Maryland
Toronto Gen Hosp
Natl Inst Cardiol
Slovak Inst Cardiovasc Dis
Vancouver Gen Hosp
Maryland Med Res Inst
Kufera Consulting Inc
Universidade Federal de São Paulo (UNIFESP)
Keywords: arrhythmia
death, sudden
myocardial infarction
Issue Date: 17-Feb-2009
Publisher: Lippincott Williams & Wilkins
Citation: Circulation. Philadelphia: Lippincott Williams & Wilkins, v. 119, n. 6, p. 779-U36, 2009.
Abstract: Background-The Occluded Artery Trial-Electrophysiological Mechanisms (OAT-EP) tested the hypothesis that opening a persistently occluded infarct-related artery by percutaneous coronary intervention and stenting (PCI) after the acute phase of myocardial infarction compared with optimal medical therapy alone reduces markers of vulnerability to ventricular arrhythmias.Methods and Results-Between April 2003 and December 2005, 300 patients with an occluded native infarct-related artery 3 to 28 days (median, 12 days) after myocardial infarction were randomized to PCI or optimal medical therapy. Ten-minute digital Holter recordings were obtained before randomization, at 30 days, and at 1 year. the primary end point was the change in alpha 1, a nonlinear heart rate variability parameter, between baseline and 1 year. Major secondary end points were the changes in the filtered QRS duration on the signal-averaged ECG and variability in T-wave morphology (T-wave variability) between baseline and 1 year. There were no significant differences in the changes in alpha 1 (-0.04; 95% CI, -0.12 to 0.04), filtered QRS (2.2 ms; 95% CI, -1.4 to 5.9 ms), or T-wave variability (3.0 mu V; 95% CI, -4.8 to 10.7 mu V) between the PCI and medical therapy groups (medical therapy change minus PCI change). Multivariable analysis revealed that the results were unchanged after adjustment for baseline clinical variables and medication treatments during the Holter recordings.Conclusions-PCI with stenting of a persistently occluded infarct-related artery during the subacute phase after myocardial infarction compared with medical therapy alone had no significant effect on changes in heart rate variability, the time-domain signal-averaged ECG, or T-wave variability during the first year after myocardial infarction. These findings are consistent with the lack of clinical benefit, including no reduction in sudden death, with PCI for stable patients with persistently occluded infarct-related arteries after myocardial infarction in the main OAT. (Circulation. 2009;119:779-787.)
ISSN: 0009-7322
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