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Title: Bilateral Anterior Thalamic Nucleus Lesions Are Not Protective against Seizures in Chronic Pilocarpine Epileptic Rats
Authors: Hamani, Clement [UNIFESP]
Ewerton, Flavio I. S.
Almeida, Flavia Marcolin de [UNIFESP]
Bonilha, Saulo M. [UNIFESP]
Covolan, Luciene [UNIFESP]
Cavarsan, Clarissa Fantin [UNIFESP]
Ballester, Gerson
Mello, Luiz E. [UNIFESP]
Lozano, Andres M.
Univ Toronto
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: Thalamus
Deep brain stimulation
Anterior nucleus
Issue Date: 1-Jan-2009
Publisher: Karger
Citation: Stereotactic and Functional Neurosurgery. Basel: Karger, v. 87, n. 3, p. 143-147, 2009.
Abstract: Aims: To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy. Methods: Two groups of rats were treated with bilateral AN radiofrequency thalamotomies or sham surgery 2 weeks after pilocarpine-induced status epilepticus. After the lesions, animals were videotaped from the 2nd to the 8th week after status epilepticus (total 180 h). Results: During the 6 weeks of observation, no differences in the frequency of spontaneous seizures were found between animals that had bilateral AN lesions (n = 26; 3.1 +/- 0.6 seizures per animal) and controls (n = 25; 3.0 +/- 0.6 seizures per animal; p = 0.8). Conclusions: We conclude that AN thalamotomies were not effective in reducing the frequency of seizures during the chronic phase of the pilocarpine model of epilepsy. Copyright (C) 2009 S. Karger AG, Basel
ISSN: 1011-6125
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