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|Title:||Bilateral Anterior Thalamic Nucleus Lesions Are Not Protective against Seizures in Chronic Pilocarpine Epileptic Rats|
|Authors:||Hamani, Clement [UNIFESP]|
Ewerton, Flavio I. S.
Almeida, Flavia Marcolin de [UNIFESP]
Bonilha, Saulo M. [UNIFESP]
Covolan, Luciene [UNIFESP]
Cavarsan, Clarissa Fantin [UNIFESP]
Mello, Luiz E. [UNIFESP]
Lozano, Andres M.
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Deep brain stimulation
|Citation:||Stereotactic and Functional Neurosurgery. Basel: Karger, v. 87, n. 3, p. 143-147, 2009.|
|Abstract:||Aims: To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy. Methods: Two groups of rats were treated with bilateral AN radiofrequency thalamotomies or sham surgery 2 weeks after pilocarpine-induced status epilepticus. After the lesions, animals were videotaped from the 2nd to the 8th week after status epilepticus (total 180 h). Results: During the 6 weeks of observation, no differences in the frequency of spontaneous seizures were found between animals that had bilateral AN lesions (n = 26; 3.1 +/- 0.6 seizures per animal) and controls (n = 25; 3.0 +/- 0.6 seizures per animal; p = 0.8). Conclusions: We conclude that AN thalamotomies were not effective in reducing the frequency of seizures during the chronic phase of the pilocarpine model of epilepsy. Copyright (C) 2009 S. Karger AG, Basel|
|Appears in Collections:||Em verificação - Geral|
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