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Title: Lymphocyte proliferation stimulated by activated human macrophages treated with Canova
Authors: Burbano, Rommel Rodriguez
Leal, Mariana Ferreira [UNIFESP]
Costa, Joana Borges da
Bahia, Marcelo de Oliveira
Lima de Lima, Patricia Danielle
Khayat, Andre Salim
Seligman, Igor Chamon
Assumpcao, Paulo Plmentel de
Buchi, Dorly de Freitas
Cardoso Smith, Marilia de Arruda [UNIFESP]
Fed Univ Para
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Keywords: Canova
Activated macrophages
Lymphocyte proliferation
Mitotic index
Issue Date: 1-Jan-2009
Publisher: Elsevier B.V.
Citation: Homeopathy. Oxford: Elsevier B.V., v. 98, n. 1, p. 45-48, 2009.
Abstract: Introduction: Canova (CA) is a homeopathic medication with immunomodulatory properties, recommended for patients with a depressed immune system. CA has been reported to increase in leukocyte numbers, cellular differentiation and reduction in tumor size.Aim and method. Since CA may stimulate lymphocyte differentiation, proliferation, and/or survival, the aim of the present study was to compare the mitotic index (MI) of phytohemagglutinin-stimulated human lymphocytes cultured in a medium supplemented with human macrophages activated by CA, with lymphocytes cultured in a medium without CA-treated macrophages.Results: in this study, the MI of lymphocyte cultured received the medium containing CA-stimulated macrophages showed a higher proliferation index (p < 0.01) than the lymphocytes cultured in a medium without CA-treated macrophages. Our results suggest that CA treatment, in addition to activating macrophages, indirectly induces lymphocyte proliferation and has potential as a new adjuvant therapeutic approach. Homeopathy (2009) 98, 45-48.
ISSN: 1475-4916
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