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Title: Zafirlukast Pocket Delivery Impairs the Capsule Healing Around Textured Implants in Rats
Authors: Moreira, Marcio
Fagundes, Djalma José [UNIFESP]
Simoes, Manuel de Jesus [UNIFESP]
Baiardi Mizoguti de Oliveira, Monica Cristina
Santos Previdelli, Isolde Terezinha dos
Moreira, Amanda Castilho
Plast Surg Brazilian Soc SBCP
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Maringá (UEM)
Univ Oeste Paulista Presidente Prudente Unoeste
Keywords: Mammary implants
Capsular thickness
Wistar rats
Capsule contracture
Issue Date: 1-Jan-2009
Publisher: Springer
Citation: Aesthetic Plastic Surgery. New York: Springer, v. 33, n. 1, p. 90-97, 2009.
Abstract: The aim of this study was to investigate the effects of zafirlukast on capsule thickness, collagen fiber density, and myofibroblast cell count of the healing tissue around silicone textured implants in rats.Thirty-six male Wistar rats were divided (n = 18) into two groups. in one group, two parallel incisions (1.5 cm long) were made into the right and left sides of the spine. Two pockets were then created in which shell-shaped textured implants were inserted. the left-side pocket was injected with 0.2 ml of saline solution (SSG) and the right-side pocket with a dose of 1.25 mg/kg of zafirlukast (ZLG). the other 18 rats (sham, SG) had only one pocket created, followed by the placement of an implant and injection of 0.2 ml of saline solution. the rats were euthanized on the 7th, 35th, or 90th days followed by careful dissection of the implant. the capsules and peri-implant tissues were prepared for histologic analysis. An ANOVA test and Tukey test were applied (p < 0.05).ZL was effective in impairing the capsule thickness on the 35th and 90th days compared to the other two groups (sham and saline). Not only was it effective in impairing the collagen density on the 35th and 90th days, but it also showed the same effect in the SSG (systemic); fewer myofibroblasts were counted on the 90th day in the ZLG compared to the SG group; the number of myofibroblasts was significantly lower in the ZLG than in the SSG.Pocket delivery of one dose of Zafirlukast was effective in impairing capsule formation around the textured implant.
ISSN: 0364-216X
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