Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/31130
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dc.contributor.authorRocha, Lillian Andrade da [UNIFESP]
dc.contributor.authorBarreto, Daniela Veit [UNIFESP]
dc.contributor.authorBarreto, Fellype de Carvalho [UNIFESP]
dc.contributor.authorDias, Cristiane Bitencourt
dc.contributor.authorMoyses, Rosa
dc.contributor.authorSilva, Maria Regina Regis da [UNIFESP]
dc.contributor.authorMoura, Luiz Antonio Ribeiro de [UNIFESP]
dc.contributor.authorDraibe, Sergio Antonio [UNIFESP]
dc.contributor.authorJorgetti, Vanda
dc.contributor.authorCarvalho, Aluizio Barbosa de [UNIFESP]
dc.contributor.authorCanziani, Maria Eugenia Fernandes [UNIFESP]
dc.date.accessioned2016-01-24T13:52:01Z-
dc.date.available2016-01-24T13:52:01Z-
dc.date.issued2009-01-01
dc.identifierhttp://dx.doi.org/10.2215/CJN.01630408
dc.identifier.citationClinical Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 4, n. 1, p. 105-109, 2009.
dc.identifier.issn1555-9041
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31130-
dc.description.abstractBackground and objectives: As well as being a marker of body iron stores, serum ferritin (sFerritin) has also been shown to be a marker of inflammation in hemodialysis (HD) patients. the aim of this study was to analyze whether sFerritin is a reliable marker of the iron stores present in bone marrow of HD patients.Design: Histomorphometric analysis of stored transiliac bone biopsies was used to assess iron stores by determining the number of iron-stained cells per square millimeter of bone marrow.Results: in 96 patients, the laboratory parameters were hemoglobin = 11.3 +/- 1.6 g/dl, hematocrit = 34.3 +/- 5%, sFerritin 609 +/- 305 ng/ml, transferrin saturation = 32.7 +/- 22.5%, and C-reactive protein (CRP) = 0.9 +/- 1.4 mg/dl. sFerritin correlated significantly with CRP, bone marrow iron, and time on HD treatment W = 0.006, 0.001, and 0.048, respectively). the independent determinants of sFerritin were CRP (beta-coef = 0.26; 95% CI = 24.6 to 132.3) and bone marrow iron (beta-coef = 0.32; 95% CI = 0.54 to 2.09). Bone marrow iron was higher in patients with sFerritin >500 ng/ml than in those with sFerritin :5500 ng/ml. in the group of patients with sFerritin :5500 ng/ml, the independent determinant of sFerritin was bone marrow iron (beta-coef = 0.48, 95% CI = 0.48 to 1.78), but in the group of patients with sFerritin >500 ng/ml, no independent determinant of sFerritin was found.Conclusions: sFerritin adequately reflects iron stores in bone marrow of HD patients.en
dc.description.sponsorshipGenzyme Corporation, Carnbridge, Massachusetts, USA
dc.description.sponsorshipOswaldo Ramos Foundation, São Paulo, Brazil
dc.format.extent105-109
dc.language.isoeng
dc.publisherAmer Soc Nephrology
dc.relation.ispartofClinical Journal of the American Society of Nephrology
dc.rightsAcesso aberto
dc.titleSerum Ferritin Level Remains a Reliable Marker of Bone Marrow Iron Stores Evaluated by Histomorphometry in Hemodialysis Patientsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Internal Med, Div Pathol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Internal Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Internal Med, Div Pathol, São Paulo, Brazil
dc.identifier.doi10.2215/CJN.01630408
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000262681200018
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