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Title: Serum Ferritin Level Remains a Reliable Marker of Bone Marrow Iron Stores Evaluated by Histomorphometry in Hemodialysis Patients
Authors: Rocha, Lillian Andrade da [UNIFESP]
Barreto, Daniela Veit [UNIFESP]
Barreto, Fellype de Carvalho [UNIFESP]
Dias, Cristiane Bitencourt
Moyses, Rosa
Silva, Maria Regina Regis da [UNIFESP]
Moura, Luiz Antonio Ribeiro de [UNIFESP]
Draibe, Sergio Antonio [UNIFESP]
Jorgetti, Vanda
Carvalho, Aluizio Barbosa de [UNIFESP]
Canziani, Maria Eugenia Fernandes [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Issue Date: 1-Jan-2009
Publisher: Amer Soc Nephrology
Citation: Clinical Journal of the American Society of Nephrology. Washington: Amer Soc Nephrology, v. 4, n. 1, p. 105-109, 2009.
Abstract: Background and objectives: As well as being a marker of body iron stores, serum ferritin (sFerritin) has also been shown to be a marker of inflammation in hemodialysis (HD) patients. the aim of this study was to analyze whether sFerritin is a reliable marker of the iron stores present in bone marrow of HD patients.Design: Histomorphometric analysis of stored transiliac bone biopsies was used to assess iron stores by determining the number of iron-stained cells per square millimeter of bone marrow.Results: in 96 patients, the laboratory parameters were hemoglobin = 11.3 +/- 1.6 g/dl, hematocrit = 34.3 +/- 5%, sFerritin 609 +/- 305 ng/ml, transferrin saturation = 32.7 +/- 22.5%, and C-reactive protein (CRP) = 0.9 +/- 1.4 mg/dl. sFerritin correlated significantly with CRP, bone marrow iron, and time on HD treatment W = 0.006, 0.001, and 0.048, respectively). the independent determinants of sFerritin were CRP (beta-coef = 0.26; 95% CI = 24.6 to 132.3) and bone marrow iron (beta-coef = 0.32; 95% CI = 0.54 to 2.09). Bone marrow iron was higher in patients with sFerritin >500 ng/ml than in those with sFerritin :5500 ng/ml. in the group of patients with sFerritin :5500 ng/ml, the independent determinant of sFerritin was bone marrow iron (beta-coef = 0.48, 95% CI = 0.48 to 1.78), but in the group of patients with sFerritin >500 ng/ml, no independent determinant of sFerritin was found.Conclusions: sFerritin adequately reflects iron stores in bone marrow of HD patients.
ISSN: 1555-9041
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