Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/31079
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dc.contributor.authorScorza, Fulvio A. [UNIFESP]
dc.contributor.authorCysneiros, Roberta M.
dc.contributor.authorArida, Ricardo M. [UNIFESP]
dc.contributor.authorScorza, Carla A. [UNIFESP]
dc.contributor.authorAlmeida, Antonio-Carlos Guimaraes de
dc.contributor.authorSchmidt, Beny [UNIFESP]
dc.contributor.authorCavalheiro, Esper A. [UNIFESP]
dc.date.accessioned2016-01-24T13:51:57Z-
dc.date.available2016-01-24T13:51:57Z-
dc.date.issued2008-12-01
dc.identifierhttp://dx.doi.org/10.1016/j.mehy.2008.06.043
dc.identifier.citationMedical Hypotheses. Edinburgh: Churchill Livingstone, v. 71, n. 6, p. 914-922, 2008.
dc.identifier.issn0306-9877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31079-
dc.description.abstractNeurogenesis persists throughout life in the adult mammalian dentate gyrus and is regulated by several environmental, physiological, and molecular factors. Seizure activity also influences dentate granule cell neurogenesis. in these tines, studies of neurogenesis have demonstrated the presence of hilar-ectopic dentate granule cells after status epilepticus induced experimentally and that these cells are migrate aberrantty, abnormally integrated and hyperexcitabte, contributing with this to seizure generation and/or propagation. As we know, epilepsy is the most common serious neurological condition and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but high seizure frequency is a potential risk factor. Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a rote. Based on these facts, in this paper we postulate that aberrant neurogenesis could influence negatively the cardiovascular system of the patient with epilepsy leading to cardiac abnormalities and hence SUDEP. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent914-922
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.rightsAcesso restrito
dc.titleAdult hippocampal neurogenesis and sudden unexpected death in epilepsy: Reality or just an attractive history?en
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUniv Fed Sao Joao Rei
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Fed Sao Joao Rei, Dept Biomed Engn, Minas Gerais, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Anat Patol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Anat Patol, BR-04023900 São Paulo, Brazil
dc.identifier.doi10.1016/j.mehy.2008.06.043
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000261164400018
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