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Title: Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder
Authors: Bloch, Michael H.
Landeros-Weisenberger, Angeli
Rosario-Campos, Maria Conceicao do [UNIFESP]
Pittenger, Christopher
Leckman, James F.
Yale Univ
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Dec-2008
Publisher: Amer Psychiatric Publishing, Inc
Citation: American Journal of Psychiatry. Arlington: Amer Psychiatric Publishing, Inc, v. 165, n. 12, p. 1532-1542, 2008.
Abstract: Objective: OCD is a clinically heterogeneous condition. This heterogeneity has the potential to reduce power in genetic, neuroimaging, and clinical trials. Despite a mounting number of studies, there remains debate regarding the exact factor structure of OCD symptoms. the authors conducted a meta-analysis to determine the factor structure of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist.Method: Studies were included if they involved subjects with OCD and included an exploratory factor analysis of the 13 Yale-Brown Obsessive Compulsive Scale Symptom Checklist categories or the items therein. A varimax-rotation was conducted in SAS 9.1 using the PROC FACTOR CORR to extract factors from sample-size weighted co-occurrence matrices. Stratified meta-analysis was conducted to determine the factor structure of OCD in studies involving children and adults separately.Results: Twenty-one studies involving 5,124 participants were included. the four factors generated were 1) symmetry: symmetry obsessions and repeating, ordering, and counting compulsions; 2) forbidden thoughts: aggression, sexual, religious, and somatic obsessions and checking compulsions, 3) cleaning: cleaning and contamination, and 4) hoarding: hoarding obsessions and compulsions. Factor analysis of studies including adults yielded an identical factor structure compared to the overall meta-analysis. Factor analysis of child-only studies differed in that checking loaded highest on the symmetry factor and somatic obsessions, on the cleaning factor.Conclusions: A four-factor structure explained a large proportion of the heterogeneity in the clinical symptoms of OCD. Further item-level factor analyses are needed to determine the appropriate placement of miscellaneous somatic and checking OCD symptoms.
ISSN: 0002-953X
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