Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/31037
Title: Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways
Authors: Sandri, Silvana
Hatanaka, Elaine
Franco, Andressa G.
Pedrosa, Alziana M. C.
Monteiro, Hugo P. [UNIFESP]
Campa, Ana
Universidade de São Paulo (USP)
Univ Cruzeiro
Universidade Federal de São Paulo (UNIFESP)
Keywords: CCL20
Mononuclear cells and serum amyloid A (SAA)
Issue Date: 16-Nov-2008
Publisher: Elsevier B.V.
Citation: Immunology Letters. Amsterdam: Elsevier B.V., v. 121, n. 1, p. 22-26, 2008.
Abstract: Although the serum levels of SAA had been reported to be upregulated during inflammatory/infectious process, the role of this acute-phase protein has not been completely elucidated. in previous studies, we demonstrated that SAA stimulated the production of TNF-alpha, IL-1 beta, IL-8, NO, and ROS by neutrophils and/or mononuclear cells. Herein we demonstrate that SAA induces the expression and release of CCL20 from Cultured human blood mononuclear cells. We also focus on the signaling pathways triggered by SAA. in THP-1 cells SAA promotes phosphorylation of p38 and ERK1/2. Furthermore, the addition of SB203580 (p38 inhibitor) and PD98059 (ERK 1/2 inhibitor) inhibits the expression and release of CCL20 in mononuclear cells treated with SAA. Our results point to SAA as an important link of innate to adaptive immunity, once it might act on the recruitment of mononuclear cells. (C) 2008 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/31037
ISSN: 0165-2478
Other Identifiers: http://dx.doi.org/10.1016/j.imlet.2008.07.013
Appears in Collections:Em verificação - Geral

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