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Title: Asbestos-related Disease Progression of Parenchymal Abnormalities on High-resolution CT
Authors: Silva, C. Isabela S.
Mueller, Nestor L.
Neder, J. Alberto [UNIFESP]
Nogueira, Cristiano Rabelo [UNIFESP]
Napolis, Lara Maris [UNIFESP]
Terra-Filho, Mario
Bagatin, Ericson
Nery, Luiz E. [UNIFESP]
Univ British Columbia
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
Jundiai Sch Med
Keywords: asbestos
computed tomography
pleural plaques
Issue Date: 1-Nov-2008
Publisher: Lippincott Williams & Wilkins
Citation: Journal of Thoracic Imaging. Philadelphia: Lippincott Williams & Wilkins, v. 23, n. 4, p. 251-257, 2008.
Abstract: Purpose: To evaluate the changes over time in the pattern and extent of parenchymal abnormalities in asbestos-exposed workers after cessation of exposure and to compare 3 proposed semiquantitative methods with a careful side-by-side comparison of the initial and the follow-Lip computed tomography (CT) images.Materials and Methods: the study included 52 male asbestos workers (mean age SD, 62.2y +/- 8.2) who had baseline high-resolution CT after cessation of exposure and follow-up CT 3 to 5 years later. Two independent thoracic radiologists quantified the findings according to the scoring systems proposed by Huuskonen, Gamsu, and Sette and then did a side-by-side comparison of the 2 sets of scans without awareness of the dates of the CT scans.Results: There was no difference in the prevalence of the 2 most common parenchymal abnormalities (centrilobular small dotlike or branching opacities and interstitial lines) between the initial and follow-up CT scans. Honeycombing (20%) and traction bronchiectasis and bronchiolectasis (50%) were seen more commonly on the follow-up CT than on the initial examination (10% and 33%, respectively) (P = 0.01). Increased extent of parenchymal abnormalities was evident on side-by-side comparison in 42 (81%) patients but resulted in an increase in score in at least 1 semiquantitative system in only 16 (31%) patients (all P > 0.01, signed test).Conclusions: the majority of patients with previous asbestos exposure show evidence of progression of disease on CT at 3 to 5 years follow-up but this progression is usually not detected by the 3 proposed semiquantitative scoring schemes.
ISSN: 0883-5993
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