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Title: MYC and gastric adenocarcinoma carcinogenesis
Authors: Calcagno, Danielle Queiroz
Leal, Mariana Ferreira [UNIFESP]
Assumpcao, Paulo Pimentel
Smith, Marilia de Arruda Cardoso [UNIFESP]
Burbano, Rommel Rodriguez
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Keywords: MYC
Gastric adenocarcinoma
Gastric preneoplastic lesions
Gastric carcinogenesis
Helicobacter pylori
Issue Date: 21-Oct-2008
Publisher: Baishideng Publ Grp Co Ltd
Citation: World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 14, n. 39, p. 5962-5968, 2008.
Abstract: MYC is an oncogene involved in cell cycle regulation, cell growth arrest, cell adhesion, metabolism, ribosome biogenesis, protein synthesis, and mitochondrial function. It has been described as a key element of several carcinogenesis processes in humans. Many studies have shown an association between MYC deregulation and gastric cancer. MYC deregulation is also seen in gastric preneoplastic lesions and thus it may have a role in early gastric carcinogenesis. Several studies have suggested that amplification is the main mechanism of MYC deregulation in gastric cancer. in the present review, we focus on the deregulation of the MYC oncogene in gastric adenocarcinorna carcinogenesis, including its association with Helicobacterpylori (Hpylorl) and clinical applications. (c) 2008 the WIG Press. All rights reserved.
ISSN: 1007-9327
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Appears in Collections:Em verificação - Geral

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