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Title: Anti-Plasmodium Activity of Angiotensin II and Related Synthetic Peptides
Authors: Maciel, Ceres
Oliveira Junior, Vani Xavier de
Fazio, Marcos Antonio [UNIFESP]
Nacif-Pimenta, Rafael
Miranda, Antonio [UNIFESP]
Pimenta, Paulo F. P.
Capurro, Margareth Lara
Universidade de São Paulo (USP)
Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Fundacao Oswaldo Cruz
Issue Date: 29-Sep-2008
Publisher: Public Library Science
Citation: Plos One. San Francisco: Public Library Science, v. 3, n. 9, 8 p., 2008.
Abstract: Plasmodium species are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research. Angiotensins I and II (ang I and ang II) and six synthetic related peptides designated Vaniceres 1-6 (VC1-VC6) were assayed in vivo and in vitro for their effects on the development of the avian parasite, Plasmodium gallinaceum. Ang II and VC5 injected into the thoraces of the insects reduced mean intensities of infection in the mosquito salivary glands by 88% and 76%, respectively. Although the mechanism(s) of action is not completely understood, we have demonstrated that these peptides disrupt selectively the P. gallinaceum cell membrane. Additionally, incubation in vitro of sporozoites with VC5 reduced the infectivity of the parasites to their vertebrate host. VC5 has no observable agonist effects on vertebrates, and this makes it a promising drug for malaria prevention and chemotherapy.
ISSN: 1932-6203
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