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Title: TNF-alpha polymorphisms are associated with obsessive-compulsive disorder
Authors: Hounie, Ana Gabriela
Cappi, Carolina
Cordeiro, Quirino
Sampaio, Aline Santos
Moraes, Ivanil
Rosario, Maria Conceicao do [UNIFESP]
Palacios, Selma A.
Goldberg, Anna Carla
Vallada, Homero Pinto
Machado-Lima, Ariane
Nakano, Eduardo
Kalil, Jorge
Pauls, David
Pereira, Carlos Alberto B.
Guilherme, Luiza
Miguel, Euripedes Constantino
Universidade de São Paulo (USP)
Harvard Univ
Universidade Federal de São Paulo (UNIFESP)
Keywords: case-control study
molecular genetics
rheumatic fever
Issue Date: 12-Sep-2008
Publisher: Elsevier B.V.
Citation: Neuroscience Letters. Clare: Elsevier B.V., v. 442, n. 2, p. 86-90, 2008.
Abstract: Introduction: Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinflammatory cytokine involved in RF and other autoimmune diseases. Polymorphisms in the promoter region of the TNFA gene have been associated with RE Given the association between OCD and RF, the goal of the present study was to investigate a possible association between polymorphisms within the promoter region of TNFA and OCD. Materials and methods: Two polymorphisms were investigated: -308 G/A and -238 G/A. the allelic and genotypic frequencies of these polymorphisms were examined in 111 patients who fulfilled DSM-IV criteria for OCD and compared with the frequencies in 250 controls. Results: Significant associations were observed between both polymorphisms and OCD. for -238 G/A, an association between the A allele and OCD was observed (X-2 = 12.05, p = 0.0005). A significant association was also observed between the A allele of the -308 G/A polymorphism and OCD (X-2 = 7.09, p = 0.007). Finally, a haplotype consisting of genotypes of these two markers was also examined. Significant association was observed for the A-A haplotype (p = 0.0099 after correcting for multiple testing). Discussion: There is association between the -308 G/A and -238 G/A TNFA polymorphisms and OCD in our Brazilian sample. However, these results need to be replicated in larger samples collected from different populations. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0304-3940
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