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Title: Centromeres in cell division, evolution, nuclear organization and disease
Authors: Santos Silva, Amanda Goncalves dos [UNIFESP]
Sarkar, Rahul
Harizanova, Jana
Guffei, Amanda
Mowat, Michael
Garini, Yuval
Mai, Sabine
Univ Manitoba
Universidade Federal de São Paulo (UNIFESP)
Sunnybrook Hlth Sci Ctr
Bar Ilan Univ
Keywords: centromere
cell division
3D nucleus
Issue Date: 15-Aug-2008
Publisher: Wiley-Blackwell
Citation: Journal of Cellular Biochemistry. Hoboken: Wiley-Blackwell, v. 104, n. 6, p. 2040-2058, 2008.
Abstract: As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and turner cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.
ISSN: 0730-2312
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Appears in Collections:Em verificação - Geral

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