Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/30852
Title: Centromeres in cell division, evolution, nuclear organization and disease
Authors: Santos Silva, Amanda Goncalves dos [UNIFESP]
Sarkar, Rahul
Harizanova, Jana
Guffei, Amanda
Mowat, Michael
Garini, Yuval
Mai, Sabine
Univ Manitoba
Universidade Federal de São Paulo (UNIFESP)
Sunnybrook Hlth Sci Ctr
Bar Ilan Univ
Keywords: centromere
cell division
evolution
cancer
3D nucleus
imaging
Issue Date: 15-Aug-2008
Publisher: Wiley-Blackwell
Citation: Journal of Cellular Biochemistry. Hoboken: Wiley-Blackwell, v. 104, n. 6, p. 2040-2058, 2008.
Abstract: As the spindle fiber attachment region of the chromosome, the centromere has been investigated in a variety of contexts. Here, we will review current knowledge about this unique chromosomal region and its relevance for proper cell division, speciation, and disease. Understanding the three-dimensional organization of centromeres in normal and turner cells is just beginning to emerge. Multidisciplinary research will allow for new insights into its normal and aberrant nuclear organization and may allow for new therapeutic interventions that target events linked to centromere function and cell division.
URI: http://repositorio.unifesp.br/handle/11600/30852
ISSN: 0730-2312
Other Identifiers: http://dx.doi.org/10.1002/jcb.21766
Appears in Collections:Em verificação - Geral

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