Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/30806
Title: Expression of vitamin D receptor mRNA in the hippocampal formation of rats submitted to a model of temporal lobe epilepsy induced by pilocarpine
Authors: Janjoppi, Luciana [UNIFESP]
Katayama, Maria Hirata
Scorza, Fulvio Alexandre [UNIFESP]
Azevedo Koike Folgueira, Maria Aparecida
Brentani, Mitzi
Pansani, Aline Priscila [UNIFESP]
Cavalheiro, Esper Abrao [UNIFESP]
Arida, Ricardo Mario [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: VDR
hippocampus
epilepsy
pilocarpine
rats
Issue Date: 30-Jul-2008
Publisher: Elsevier B.V.
Citation: Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 76, n. 5, p. 480-484, 2008.
Abstract: Vitamin D (VD), is a steroid hormone with multiple functions in the central nervous system (CNS), producing numerous physiological effects mediated by its receptor (VDR). Clinical and experimental studies have shown a link between VD dysfunction and epilepsy. Along these lines, the purpose of our work was to analyze the relative expression of VDR mRNA in the hippocampal formation of rats during the three periods of pilocarpine-induced epilepsy. Male Wistar rats were divided into five groups: (1) control group; rats that received saline 0.9%, i.p. and were killed 7 days after its administration (CTRL, n = 8), (2) SE group; rats that received pilocarpine and were killed 4 h after SE (SE, n = 8), (3) Silent group-7 days; rats that received pilocarpine and were killed 7 days after SE (SIL 7d, n = 8), (4) Silent group-14 days; rats that received pilocarpine and were killed 14 days after SE (SIL 14d, n = 8), (5) Chronic group; rats that received pilocarpine and were killed 60 days after the first spontaneous seizure, (chronic, n = 8). the relative expression of VDR mRNA was determined by real-time PCR. Our results showed an increase of the relative expression of VDR mRNA in the SIL 7 days, SIL 14 days and Chronic groups, respectively (0.060 +/- 0.024; 0.052 +/- 0.035; 0.085 +/- 0.055) when compared with the CTRL and SE groups (0.019 +/- 0.017; 0.019 +/- 0.025). These data suggest the VDR as a possible candidate participating in the epileptogenesis process of the pilocarpine model of epilepsy. (C) 2008 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/30806
ISSN: 0361-9230
Other Identifiers: http://dx.doi.org/10.1016/j.brainresbull.2008.01.002
Appears in Collections:Em verificação - Geral

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