Please use this identifier to cite or link to this item:
Title: Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis
Authors: Okamoto, Oswaldo Keith [UNIFESP]
Perez, Jose Fernando [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: biotechnology
cancer stem cell
molecular imaging
monoclonal antibody
target therapy
Issue Date: 1-Jul-2008
Publisher: Expert Reviews
Citation: Expert Review of Molecular Diagnostics. London: Expert Reviews, v. 8, n. 4, p. 387-393, 2008.
Abstract: This review discusses some of the impacts that biotechnology, genomics and nanotechnology convergence should have on future cancer management, in particular, the development of innovative diagnostic and therapeutic approaches based on monoclonal antibodies (mAbs) and cancer stem cells. Emergent therapeutic strategies in cancer have been focusing on the use of mAbs to stimulate an immune response against tumors, to block signaling pathways, or to refine delivery of cytotoxic agents. Now that cancer stem cells are being identified and characterized in different tumor types, their relevance to cancer physiopathology is becoming evident, making them natural targets for mAb development. Cancer stem cells are postulated to be responsible for tumor development, metastasis and relapse after conventional therapies. Therefore, mAbs targeting specific antigens and related pathways altered in cancer stem cells should facilitate earlier diagnosis through molecular imaging techniques and more efficient destruction of tumor initiating cells, thus improving clinical outcome.
ISSN: 1473-7159
Other Identifiers:
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.