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Title: Temporal lobe epilepsy and social behavior: An animal model
Authors: Marin, Joao Carlos M. [UNIFESP]
Moura, Paula J.
Cysneiros, Roberta M.
Colugnati, Diego Basile [UNIFESP]
Cavalheiro, Esper A.
Scorza, Fulvio A.
Xavier, Gilberto F.
Zilbovicius, Monica
Mercadante, Marcos T. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: temporal lobe epilepsy
social behavior
social inemory
social discrimination paradigm
autism animal model
Issue Date: 1-Jul-2008
Publisher: Elsevier B.V.
Citation: Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 13, n. 1, p. 43-46, 2008.
Abstract: Social behavior depends on the integrity of social brain circuitry. the temporal lobe is an important part of the social brain, and manifests morphological and functional alterations in autism spectrum disorders (ASD). Rats with temporal lobe epilepsy (TLE), induced with pilocarpine, were subjected to a social discrimination test that has been used to investigate potential animal models of ASD, and the results were compared with those for the control group. Rats with TLE exhibited fewer social behaviors than controls. No differences were observed in nonsocial behavior between groups. the results suggest an important role for the temporal lobe in regulating social behaviors. This animal model might be used to explore some questions about ASD pathophysiology. (c) 2008 Elsevier Inc. All rights reserved.
ISSN: 1525-5050
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