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Title: Progesterone receptor (PROGINS) polymorphism and the risk of ovarian cancer
Authors: Leite, Daniela B. [UNIFESP]
Junqueira, Michele G. [UNIFESP]
Carvalho, Cristina V. de [UNIFESP]
Massad-Costa, Ana M. [UNIFESP]
Gongalues, Wagner J. [UNIFESP]
Nicolau, Sergio M. [UNIFESP]
Lopes, Luiz A. E. [UNIFESP]
Baracat, Edmundo C. [UNIFESP]
Silva, Ismael D. C. G. da [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: ovarian cancer
Issue Date: 1-Jul-2008
Publisher: Elsevier B.V.
Citation: Steroids. New York: Elsevier B.V., v. 73, n. 6, p. 676-680, 2008.
Abstract: The present case-control study evaluates the role of the progesterone receptor (PR) polymorphism known as PROGINS as a risk factor for ovarian cancer development and investigates the association between these genetic variants and clinical/pathologic variables of ovarian cancer. PROGINS polymorphism was examined, by polymerase chain reaction, in a total of 80 patients with ovarian cancer and 282 control subjects. the frequencies of PROGINS polymorphism T1/T1, T1/T2, and T2/T2 were 71.3, 15.0 and 13.8% in ovarian cancer patients and 78.37, 21.63 and 0% in controls, respectively the chi(2)-test showed a higher incidence of the T2/T2 genotype (P=0.001) in the ovarian cancer group. in addition, women carrying a mutated allele (T2) showed approximately 2.2 times higher risk of ovarian cancer development as compared to women who have a variant allele (odds ratio (OR) = 2.2; 95% CI = 1.80-3.54). Regarding the clinical and pathologic findings observed within the cancer group, there was a significant correlation between PROGINS polymorphism and patients with a familial history (chi(2) = 6.776; P = 0.009; Fischer exact test, P = 0.01). in this regard, patients with familial antecedents have a 4.7 times higher likelihood to have at least one risk allele (T2) as compared with patients without familial antecedents (OR = 4.69; 95% CI = 1.38-15.87). No correlations were observed among the other variables. These data suggest that the PROGINS polymorphism T2/T2 genotype might be associated with an increased risk of ovarian cancer. (C) 2008 Elsevier Inc. All rights reserved.
ISSN: 0039-128X
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