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Title: High levels of Granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment
Authors: Guzman, Valeska B. [UNIFESP]
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Brenna, Sylvia M. F.
Carvalho, Carmen R. N. [UNIFESP]
Ribalta, Julisa Chamorro Lascalas [UNIFESP]
Gerbase-Lima, Maria [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Leonor Mendes Barros Hosp
Keywords: Granzyme B
clinical outcome
cervical cancer
Issue Date: 1-Jun-2008
Publisher: Taylor & Francis Inc
Citation: Cancer Investigation. Philadelphia: Taylor & Francis Inc, v. 26, n. 5, p. 499-503, 2008.
Abstract: The present study assessed, in cervical carcinoma, expression levels of seven immune response genes and sought correlation to response to treatment. the expression levels of C,026, CTLA4, ICOS, ICOSL, CD80 and CD86 and granzyme B genes were assessed by real-time RTPCR in pre-treatment tumor fragments. During the six-month follow-up after treatment, 8 patients presented tumor and 10 survived free of tumor. the only gene whose expression levels, were higher in patients with poor outcome (p = 0.03) was granzyme B. Further evaluation, in adequately powered prospective studies is warranted to confirm the data and to translate this observation to the clinical setting.
ISSN: 0735-7907
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Appears in Collections:Em verificação - Geral

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