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Title: Bone marrow cells are able to increase vessels number during repair of sciatic nerve lesion
Authors: Fernandes, Marcela [UNIFESP]
Valente, Sandra Gomes [UNIFESP]
Silva Fernandes, Maria Jose da [UNIFESP]
Villar Felix, Evandro Penteado [UNIFESP]
Naffah Mazzacoratti, Maria da Graca [UNIFESP]
Scerni, Debora Amado [UNIFESP]
Gomes dos Santos, Joao Baptista [UNIFESP]
Leite, Vilnei Mattioli [UNIFESP]
Faloppa, Flavio [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: bone marrow cells
nerve regeneration
sciatic nerve
Issue Date: 15-May-2008
Publisher: Elsevier B.V.
Citation: Journal of Neuroscience Methods. Amsterdam: Elsevier B.V., v. 170, n. 1, p. 16-24, 2008.
Abstract: The aim of this study was to compare the outcomes of nerve autografts (GRF) and venous grafts containing mononuclear bone marrow cells (BMCs) in sciatic nerve-lesioned rats. Control animals underwent sham operations (SHAM), received empty venous grafts (EPV), or received venous grafts containing BMC vehicle (AGR). Outcome was evaluated through sciatic functional index (SIFI), morphometric and morphologic analyses of the nerve distal to the lesion, and the number of spinal cord motor neurons positive for the retrograde tracer, Fluoro-Gold (R). All groups exhibited poor results in SFI when compared to SHAM animals throughout the postoperative period. All groups also had a significantly greater fiber density, decreased fiber diameter, and decreased motor neuron number than the SHAM group. No significant difference between the GRF and BMC groups was observed in any of these parameters. On the other hand, vessel density was significantly higher in BMC than all other groups. BMC-containing venous grafts are superior to nerve autografts in increasing vessel density during sciatic nerve regeneration. (c) 2007 Elsevier B.V. All rights reserved.
ISSN: 0165-0270
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