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Title: The effect of early virological response in health-related quality of life in HCV-infected patients
Authors: Quarantini, Lucas C. [UNIFESP]
Miranda-Scippa, Angela
Batista-Neves, Susana
Galvao-De-Almeida, Amanda
Lacerda, Acioly L. [UNIFESP]
Moriyama, Tais S. [UNIFESP]
Sampaio, Aline S.
Melcop, Ana C. [UNIFESP]
Schinoni, Maria I.
Oliveira, Irismar R. de
Parana, Raymundo
Bressan, Rodrigo A. [UNIFESP]
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: hepatitis C
interferon alpha
quality of life
Issue Date: 1-Mar-2008
Publisher: Wiley-Blackwell
Citation: Journal of Medical Virology. Hoboken: Wiley-liss, v. 80, n. 3, p. 419-423, 2008.
Abstract: Twenty-nine HCV-infected patients were treated with pegylated interferon alpha. Diagnosis was based on serum HCV RNA-PCR positive results and liver biopsy. All patients had elevated serum levels of alanine aminotransferase at the time of the study, but liver disease was compensated. Patients were evaluated at baseline treatment and after 4 and 12 weeks of antiviral treatment with the Medical Outcomes Study 36-item Short-Form Health Survey. the Mini-International Neuropsychiatric Interview was used to exclude previous or current psychiatric diagnoses. Both patients and psychiatrists were blind to the HCV RNA status, and serum HCV RNA test results only became available after the visit at week 12. After antiviral treatment, 16 patients (55.2%) were classified as nonresponders and 13 (44.8%) were classified as responders. When compared to nonresponders, responders had a greater improvement in the HRQOL scores for the mental health domain (P<.019). Differences in other domains were not significant. the present study confirms that active viral infection is one possible reason for the poor Health-Related Quality of Life in this population.
ISSN: 0146-6615
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Appears in Collections:Em verificação - Geral

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