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Title: Morphologic and clinical effects of subretinal injection of indocyanine green and infracyanine green in rabbits
Authors: Penha, Fernando M. [UNIFESP]
Maia, Mauricio [UNIFESP]
Farah, Michel E. [UNIFESP]
Dib, Eduardo [UNIFESP]
Principe, Andre H. [UNIFESP]
Devin, Fracois
Rodrigues, Eduardo B.
Duprat, Joao P. [UNIFESP]
Freymueller, Edna [UNIFESP]
Hosp Reg San Jose
Universidade Federal de São Paulo (UNIFESP)
Ctr Paradis Monticelli
Issue Date: 1-Feb-2008
Publisher: Mary Ann Liebert Inc
Citation: Journal of Ocular Pharmacology and Therapeutics. New Rochelle: Mary Ann Liebert Inc, v. 24, n. 1, p. 52-61, 2008.
Abstract: Purpose: the aim of this study was to determine the effects of subretinal injection of indocyanine green (ICG), infracyanine (IfCG), and balanced salt solution (BSS) in rabbits.Methods: Ten (10) animals were subjected to a subretinal injection of 0.05% ICG (279 mOsm), 0.5% IfCG (276 mOsm), and BSS (300 mOsm) used as a control. Animals were examined at 6, 12, and 24 h and 14 days following the surgical procedure by indirect binocular ophthalmoscopy, fluorescein angiography (FA), and light and transmission electron microscopy.Results: the subretinal injection of ICG caused damage to all retinal layers and retinal pigment epithelium (RPE) during the entire follow-up. Subretinal injection of IfCG resulted in abnormalities of the photoreceptor outer segments (POSs) during the entire follow-up; however, abnormalities of the photoreceptor inner segments (PISs) and outer nuclear layer (ONL) were observed only 24 h and 14 days after surgery; no RPE damage was observed. FA showed that window defects were more prominent in the subretinal ICG bleb position than the IfCG-related area. BSS caused only abnormalities of the POS layer and no RPE alterations.Conclusions: Subretinal injection of 0.05% ICG results in more significant retinal damage than 0.5% IfCG. in this model, iodine-free IfCG demonstrates a safer profile than a tenfold lower concentration of ICG, which contains iodine in its composition.
ISSN: 1080-7683
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Appears in Collections:Em verificação - Geral

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