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dc.contributor.authorRaiol, Lauren Claudia Costa
dc.contributor.authorSilva, Evely Cristina Figueira
dc.contributor.authorDa Fonseca, Diana Mendes
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorGuimaraes, Adriana Costa
dc.contributor.authorCalcagno, Danielle Queiroz
dc.contributor.authorKhayat, Andre Salim
dc.contributor.authorAssumpcao, Paulo Pimentel
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.identifier.citationCancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 181, n. 1, p. 31-35, 2008.
dc.description.abstractGastric cancer is the second leading cause of death by cancer in Brazil. Early gastric cancer represents similar to 10% of gastric cancer cases in some services of Brazil, which underscores the need for early gastric cancer diagnosis that could lead to better prognosis. There are few published studies of cytogenetic alterations in early gastric cancer. To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil. Three signals of MYC and MYC immunoreactivity were observed in all five samples, regardless of histologic type, tumor extension, or lymph nodal status. These novel findings concerning MYC copy number alteration in early gastric cancer suggest that MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target. (c) 2008 Elsevier Inc. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Genetics and Cytogenetics
dc.rightsAcesso restrito
dc.titleInterrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinomaen
dc.contributor.institutionFed Univ Para
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationFed Univ Para, Inst Biol Sci, Human Cytogenet & Toxicol Genet Lab, BR-66075900 Belem, Para, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol, Div Genet, São Paulo, SP, Brazil
dc.description.affiliationFed Univ Para, Joao Barros Barreto Univ Hosp, Belem, Para, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol, Div Genet, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
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